Biological response genes after single dose administration of interferon β-1b to healthy male volunteers
| Autor: | Susanne Schwenke, Johannes Lampe, Rupert Sandbrink, Joachim Reischl, Jan Hilpert, Kristin Kowal, Jürgen F. Heubach, Johanna M. Beekman, Steffen Stürzebecher, David Bauer |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Drug media_common.quotation_subject Immunology Gene Expression Pharmacology Placebo law.invention Adjuvants Immunologic Double-Blind Method Randomized controlled trial law Interferon medicine Humans Immunologic Factors Immunology and Allergy Oligonucleotide Array Sequence Analysis media_common Principal Component Analysis Reverse Transcriptase Polymerase Chain Reaction business.industry Gene Expression Profiling Multiple sclerosis Interferon-beta medicine.disease Neurology Mechanism of action Gene chip analysis Biomarker (medicine) Neurology (clinical) medicine.symptom business Interferon beta-1b medicine.drug |
| Zdroj: | Journal of Neuroimmunology. 199:115-125 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2008.04.036 |
| Popis: | Treatment with interferon β-1b (IFNB-1b) is clinically effective in multiple sclerosis patients. However, the mechanism of action is only partially understood, and validated biological response markers are lacking. We assessed IFNB-1b-induced transcriptional changes by microarray technology. Healthy male volunteers received 250 μg IFNB-1b or placebo in a double-blind, randomized controlled trial ( n = 5 per group). Most transcripts demonstrated peak levels after 6–12 h and returned to baseline after 48 h. We identified 227 differentially regulated genes including novel and previously described markers. This panel may become a valuable tool for development of new IFNB-1b formulations and assessment of clinical drug effects. |
| Databáze: | OpenAIRE |
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