Genetics and Epigenetics in the Clinic: Precision Medicine in the Management of Fatty Liver Disease
| Autor: | Luca Valenti, A. Cespiati, Neil A. Youngson, Aikaterini Tourna |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Carcinoma
Hepatocellular Disease 01 natural sciences Epigenesis Genetic 03 medical and health sciences Liver disease Non-alcoholic Fatty Liver Disease Drug Discovery Nonalcoholic fatty liver disease Medicine Humans Epigenetics Precision Medicine 030304 developmental biology Pharmacology Genetics 0303 health sciences business.industry Fatty liver Liver Neoplasms Disease Management Precision medicine medicine.disease digestive system diseases 0104 chemical sciences 3. Good health Biomarker (cell) 010404 medicinal & biomolecular chemistry Personalized medicine business |
| Zdroj: | Current pharmaceutical design. 26(10) |
| ISSN: | 1873-4286 |
| Popis: | This narrative review will discuss the current evidence supporting the possible application of precision or personalized medicine to the management of nonalcoholic or “metabolic” fatty liver disease (NAFLD), based on recent progress in the understanding of the genetics and epigenetics of the disease. The prevalence of NAFLD, which can progress to cirrhosis and hepatocellular carcinoma, is constantly increasing worldwide. Accurate noninvasive predictors of liver disease progression, as well as of cardiovascular complications of NAFLD, are urgently needed. Evidence is now reporting that the genetic and epigenetic factors involved in NAFLD development can be used to develop risk scores for liver-related complications, which may show the possibility to implement programs for targeted screening and surveillance of complications. Moreover, genetic and epigenetic factors identifying specific sub-phenotypes of NAFLD can predict the individual response to pharmacological therapies. Finally, we describe opportunities for gene-targeted therapeutic approaches in NAFLD, where the genetic variants represent therapeutic targets for precision therapy approaches. |
| Databáze: | OpenAIRE |
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