The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models
| Autor: | Boris Kantor, Gabriella MacDougall, Logan Y. Brown, Ornit Chiba-Falek |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Induced Pluripotent Stem Cells
Rodentia Disease Review 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Age related Drug Discovery Genetics Medicine Animals Humans Induced pluripotent stem cell Molecular Biology 030304 developmental biology Pharmacology 0303 health sciences business.industry Drug discovery Parkinson Disease Clinical trial Disease Models Animal 030220 oncology & carcinogenesis Molecular Medicine business Neuroscience Stem Cell Transplantation |
| Zdroj: | Mol Ther |
| ISSN: | 1525-0024 |
| Popis: | Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most prevalent age-related neurodegenerative diseases, and currently no effective clinical treatments exist for either, despite decades of clinical trials. The failure to translate preclinical findings into effective treatments is indicative of a problem in the current evaluation pipeline for potential therapeutics. At present, there are no useful animal models for AD and PD research that reflect the entire biology of the diseases, specifically, the more common non-Mendelian forms. Whereas the field continues to seek suitable rodent models for investigating potential therapeutics for these diseases, rodent models have still been used primarily for preclinical studies. Here, we advocate for a paradigm shift toward the application of human-induced pluripotent stem cell (hiPSC)-derived systems for PD and AD modeling and the development of improved human-based models in a dish for drug discovery and preclinical assessment of therapeutic targets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|