Effects of vitamin C on muscle glycogen and oxidative events in experimental diabetes
| Autor: | Çiğdem Özer, E. Bulduk, Bilge Gönül |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Blood Glucose
Male Vitamin medicine.medical_specialty Clinical chemistry Clinical Biochemistry Ascorbic Acid Nitric Oxide Diabetes Mellitus Experimental chemistry.chemical_compound Malondialdehyde Diabetes mellitus Internal medicine medicine TBARS Animals Rats Wistar Muscle Skeletal Molecular Biology Soleus muscle Vitamin C Glycogen business.industry Body Weight Organ Size Cell Biology General Medicine medicine.disease Streptozotocin Glutathione Rats Endocrinology chemistry business Oxidation-Reduction medicine.drug |
| Zdroj: | Molecular and Cellular Biochemistry. 292:131-137 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/s11010-006-9226-3 |
| Popis: | Streptozotocin (STZ) is an agent used in creating experimental diabetes. Varying findings have been reported about the striated muscle glycogen levels in diabetes. In this study, it was planned to observe interaction of vitamin C (AA), of which deficiency has been shown in diabetics, with soleus muscle glycogen levels and oxidative events on STZ-diabetic subjects. Material and Method: In the study, 38 male adult Wistar Albino rats with weights 200 +/- 20 g were used by separating them into four groups: Control, Vitamin C, Diabetes, Diabetes + Vitamin C. Body weights and fasting blood glucose were measured at the beginning and end of the experiment. AA, TBARS, GSH, NOx and glycogen levels of soleus muscles, and AA level of blood were measured. The results were compared using Anova variance and Mann-Whitney U tests. Results showed that AA levels in blood increased with vitamin C administration; AA, GSH and NOx levels in the muscle were low and MDA and glycogen levels were high in diabetics; and that vitamin C in the given dosage partially corrected these values. These results indicate that higher dosage than daily 20 mg/kg Vitamin C is required for being effective on metabolic and oxidizing events in diabetic rats. |
| Databáze: | OpenAIRE |
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