A High-Resolution Spatiotemporal Atlas of Gene Expression of the Developing Mouse Brain
| Autor: | Paul Wohnoutka, Thuc Nghi Nguyen, Lydia Ng, Jeremy A. Miller, Amy Bernard, Almudena Martinez-Ferre, Raquel Garcia-Lopez, Zackery L. Riley, Michael Hawrylycz, Andrew Sodt, Katie J. Glattfelder, Damon T. Page, R.D. Young, Allan R. Jones, Leonard Kuan, Susan M. Sunkin, Nick Dee, Salvador Martinez, Jolene Kidney, John G. Hohmann, Alex M. Henry, Andreas Jeromin, Simon Smith, Carol L. Thompson, Christopher Lau, Geri Orta, Kimberly A. Smith, Vilas Menon, John L.R. Rubenstein, Chinh Dang, Ana Pombero, Wayne Wakeman, Changkyu Lee, Ajamete Kaykas, Luis Puelles |
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| Jazyk: | angličtina |
| Předmět: |
Neuroscience(all)
1.1 Normal biological development and functioning Gene Expression In situ hybridization Biology Brain mapping Article Mice Underpinning research Gene expression Genetics Psychology Animals Developmental Gene Pediatric Regulation of gene expression Brain Mapping Neurology & Neurosurgery Developmental age Gene Expression Profiling General Neuroscience Brain atlas Neurosciences Brain Gene Expression Regulation Developmental Gene expression profiling Gene Expression Regulation Neurological Cognitive Sciences Neuroscience Biotechnology |
| Zdroj: | Neuron, vol 83, iss 2 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2014.05.033 |
| Popis: | et al. To provide a temporal framework for the genoarchitecture of brain development, we generated in situ hybridization data for embryonic and postnatal mouse brain at seven developmental stages for ∼2,100 genes, which were processed with an automated informatics pipeline and manually annotated. This resource comprises 434,946 images, seven reference atlases, an ontogenetic ontology, and tools to explore coexpression of genes across neurodevelopment. Gene sets coinciding with developmental phenomena were identified. A temporal shift in the principles governing the molecular organization of the brain was detected, with transient neuromeric, plate-based organization of the brain present at E11.5 and E13.5. Finally, these data provided a transcription factor code that discriminates brain structures and identifies the developmental age of a tissue, providing a foundation for eventual genetic manipulation or tracking of specific brain structures over development. The resource is available as the Allen Developing Mouse Brain Atlas (http://developingmouse.brain-map.org). |
| Databáze: | OpenAIRE |
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