Tumor Immune Microenvironment and Its Related miRNAs in Tumor Progression
| Autor: | Lufeng Zheng, Guojing Ruan, Yantong Zhou, Xi Tao, Jiamin Shang, Yingying Xing, Hai Qin, Haiwei Ni, Xinyue Gu, Simiao Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Immunology Antineoplastic Agents tumor progression Review Biology law.invention Immune system Lymphocytes Tumor-Infiltrating law Neoplasms microRNA medicine Tumor Microenvironment Immunology and Allergy Animals Humans dendritic cells miRNA tumor immune microenvironment natural killer cells tumor-associated macrophages Myeloid-Derived Suppressor Cells Cancer Immunotherapy RC581-607 medicine.disease Killer Cells Natural MicroRNAs Phenotype Tumor progression Myeloid-derived Suppressor Cell Cancer research Disease Progression Suppressor Tumor Escape Immunologic diseases. Allergy CD8 |
| Zdroj: | Frontiers in Immunology, Vol 12 (2021) Frontiers in Immunology |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2021.624725/full |
| Popis: | MiRNA is a type of small non-coding RNA, by regulating downstream gene expression that affects the progression of multiple diseases, especially cancer. MiRNA can participate in the biological processes of tumor, including proliferation, invasion and escape, and exhibit tumor enhancement or inhibition. The tumor immune microenvironment contains numerous immune cells. These cells include lymphocytes with tumor suppressor effects such as CD8+ T cells and natural killer cells, as well as some tumor-promoting cells with immunosuppressive functions, such as regulatory T cells and myeloid-derived suppressor cells. MiRNA can affect the tumor immune microenvironment by regulating the function of immune cells, which in turn modulates the progression of tumor cells. Investigating the role of miRNA in regulating the tumor immune microenvironment will help elucidate the specific mechanisms of interaction between immune cells and tumor cells, and may facilitate the use of miRNA as a predictor of immune disorders in tumor progression. This review summarizes the multifarious roles of miRNA in tumor progression through regulation of the tumor immune microenvironment, and provides guidance for the development of miRNA drugs to treat tumors and for the use of miRNA as an auxiliary means in tumor immunotherapy. |
| Databáze: | OpenAIRE |
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