Factors Affecting Image Quality and Lesion Evaluability in Breast Diffusion-weighted MRI: Observations from the ECOG-ACRIN Cancer Research Group Multisite Trial (A6702)
Autor: | Basak E. Dogan, Linda Moy, Thomas L. Chenevert, Bonnie N. Joe, Wei T. Yang, Habib Rahbar, Nola M. Hylton, Christopher Comstock, Karen Y. Oh, Jennifer G. Whisenant, Lilian C. Wang, Sara M. Harvey, Luminita A. Tudorica, Savannah C. Partridge, Elizabeth S. McDonald, Dariya I. Malyarenko, Justin Romanoff, Thomas E. Yankeelov, Wendy B. DeMartini, Lisa J. Wilmes, Colleen H. Neal, Averi E. Kitsch |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Image quality Low Confidence Clinical Trials and Supportive Activities artifacts 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences multicenter trial 0302 clinical medicine diagnostic performance Clinical Research Multicenter trial Breast Cancer medicine Effective diffusion coefficient Breast MRI Radiology Nuclear Medicine and imaging breast magnetic resonance imaging Cancer Original Research screening and diagnosis Radiological and Ultrasound Technology Receiver operating characteristic medicine.diagnostic_test business.industry Detection 030220 oncology & carcinogenesis apparent diffusion coefficient Biomedical Imaging Radiology medicine.symptom business 4.2 Evaluation of markers and technologies Diffusion MRI |
Zdroj: | J Breast Imaging Journal of breast imaging, vol 3, iss 1 |
ISSN: | 2631-6129 2631-6110 |
Popis: | Objective The A6702 multisite trial confirmed that apparent diffusion coefficient (ADC) measures can improve breast MRI accuracy and reduce unnecessary biopsies, but also found that technical issues rendered many lesions non-evaluable on diffusion-weighted imaging (DWI). This secondary analysis investigated factors affecting lesion evaluability and impact on diagnostic performance. Methods The A6702 protocol was IRB-approved at 10 institutions; participants provided informed consent. In total, 103 women with 142 MRI-detected breast lesions (BI-RADS assessment category 3, 4, or 5) completed the study. DWI was acquired at 1.5T and 3T using a four b-value, echo-planar imaging sequence. Scans were reviewed for multiple quality factors (artifacts, signal-to-noise, misregistration, and fat suppression); lesions were considered non-evaluable if there was low confidence in ADC measurement. Associations of lesion evaluability with imaging and lesion characteristics were determined. Areas under the receiver operating characteristic curves (AUCs) were compared using bootstrapping. Results Thirty percent (42/142) of lesions were non-evaluable on DWI; 23% (32/142) with image quality issues, 7% (10/142) with conspicuity and/or localization issues. Misregistration was the only factor associated with non-evaluability (P = 0.001). Smaller (≤10 mm) lesions were more commonly non-evaluable than larger lesions (p Conclusion Image quality remains a technical challenge in breast DWI, particularly for smaller lesions. Protocol optimization and advanced acquisition and post-processing techniques would help to improve clinical utility. |
Databáze: | OpenAIRE |
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