Tumor-associated macrophage related interleukin-6 in cerebrospinal fluid as a prognostic marker for glioblastoma
| Autor: | Hiroshi Yokozaki, Satoshi Nakamizo, Yu-ichiro Koma, Hiroaki Nagashima, Takanori Hirose, Takashi Sasayama, Yuichi Fujita, Hirotomo Tanaka, Masamitsu Nishihara, Tatsuo Hori, Kazuhiro Tanaka, Eiji Kohmura, Masahiro Maeyama |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Adolescent Angiogenesis Tumor-associated macrophage Young Adult 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Cell Movement Physiology (medical) Glioma Biomarkers Tumor medicine Humans Interleukin 6 Aged Aged 80 and over High concentration biology Brain Neoplasms Interleukin-6 business.industry Macrophages General Medicine Middle Aged Prognosis medicine.disease nervous system diseases Neurology 030220 oncology & carcinogenesis biology.protein Cancer research Female Surgery Neurology (clinical) Antibody Glioblastoma business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Neuroscience. 68:281-289 |
| ISSN: | 0967-5868 |
| DOI: | 10.1016/j.jocn.2019.07.020 |
| Popis: | Interleukin-6 (IL-6) is one of the pleiotropic cytokines and has received attention as a critical factor implicated in the invasion and the angiogenesis of various cancers. In glioma, IL-6 is known to be associated with the prognosis; however, the roles of IL-6 in cerebrospinal fluid (CSF) has not been studied sufficiently. We examined the concentration of CSF IL-6 using 75 CSF samples of glioma (54 glioblastomas (GBMs) and 21 other grades of gliomas) and analyzed the association CSF IL-6 with infiltration levels of tumor-associated macrophages (TAMs) and prognosis. The concentration of CSF IL-6 in GBM patients was significantly higher than that in other grades of gliomas. CSF IL-6 levels were associated with the infiltration rate of TAMs in GBMs, and IL-6 levels were increased in the GBM cells co-cultured with TAM-like macrophages. The CSF of GBM patients, which contained high concentration of IL-6, promoted the migration ability of GBM cells, and neutralization antibodies of IL-6 inhibited its migration ability. Finally, in both univariate and multivariate analysis, higher CSF IL-6 levels were associated with poorer prognosis in GBM patients. These results indicated that the concentration of CSF IL-6 is associated with TAMs' infiltration level and may be a useful prognostic biomarker for the GBM patients. |
| Databáze: | OpenAIRE |
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