Transgenerational Effects of Two Antidepressants (Sertraline and Venlafaxine) on Daphnia magna Life History Traits
| Autor: | Christelle Dubreule, Céline Ballandonne, Marie-Pierre Halm-Lemeille, Christiane Rakotomalala, Laetitia Minguez, Valérie Kientz-Bouchart |
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| Přispěvatelé: | Centre d'Etudes et de Recherche sur le Médicament de Normandie (CERMN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), LABÉO, Pôle d’analyses et de recherche de Normandie (LABÉO), ANR-10-CESA-0013,Pharm@ecotox,Résidus pharmaceutiques et écotoxicologie en milieu marin(2010) |
| Rok vydání: | 2015 |
| Předmět: |
Offspring
Serotonin reuptake inhibitor Population Dynamics Daphnia magna Physiology Venlafaxine Environment 010501 environmental sciences Pharmacology Biology 01 natural sciences 03 medical and health sciences Drug tolerance Sertraline medicine Animals Environmental Chemistry 14. Life underwater 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Reproduction Venlafaxine Hydrochloride General Chemistry Fecundity biology.organism_classification Antidepressive Agents Fertility Daphnia Maternal Exposure [SDE]Environmental Sciences Female Reuptake inhibitor medicine.drug |
| Zdroj: | Environmental Science and Technology Environmental Science and Technology, American Chemical Society, 2015, 49 (2), pp.1148-1155. ⟨10.1021/es504808g⟩ |
| ISSN: | 1520-5851 0013-936X |
| DOI: | 10.1021/es504808g |
| Popis: | International audience; The low levels of antidepressants detected in surface waters currently raise concern about their potential long-term risks to nontarget aquatic organisms. We investigated the transgenerational effects of sertraline, a selective serotonin reuptake inhibitor, and venlafaxine, a serotonin-norepinephrine reuptake inhibitor, on the life traits of Daphnia magna over two generations under environmentally realistic concentrations. We also studied the reversibility of the effect using recovery experiments. We assessed daphnid survival, growth, and reproduction over 21 days and evidenced detectable effects of the antidepressants. Sertraline increased the F0-daphnid fecundity whereas it decreased the offspring number of F1-daphnids. Transfer to clean medium caused negative effects on the offspring of daphnids exposed to 0.3 μg L(–1), but improved the fecundity of offspring of daphnids exposed to 100 μg L(–1). Venlafaxine exposure decreased the offspring number of F0-daphnids and resulted in drug tolerance in the F1 generation. Sertraline, unlike venlafaxine, may turn out to be a true environmental threat due to its accumulation in algae and the physiological weakness observed over generations. These effects across generations point out to the need to perform multigeneration tests to assess the environmental risk of pharmaceuticals in nontarget organisms |
| Databáze: | OpenAIRE |
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