Sulfonamide derivatives as multi-target agents for complex diseases
| Autor: | Sinem Apaydın, Marianna Török |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Antifungal
medicine.drug_class Clinical Biochemistry Antibiotics Pharmaceutical Science Computational biology 01 natural sciences Biochemistry Multi target Cell Line Tumor Drug Discovery medicine Animals Humans Polypharmacology Molecular Biology Repurposing Sulfonamides Prontosil 010405 organic chemistry Drug discovery Chemistry Organic Chemistry Sulfonamide (medicine) 0104 chemical sciences 010404 medicinal & biomolecular chemistry Molecular Medicine medicine.drug |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 29:2042-2050 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2019.06.041 |
| Popis: | Sulfonamide derivatives are frequently seen structural motifs in medicinal chemistry. Almost a century after Gerhard Domagk's pioneering work leading to the first sulfonamide antibiotic Prontosil, sulfa-drugs are still widely utilized in various pharmaceutical applications due to their antibacterial, antiviral, antimalarial, antifungal, anticancer, antidepressant, or other properties. In the past few years, the interest in sulfonamides has increased as their broad range of bioactivity and versatile structure make them excellent candidates for repurposing old drugs or developing new multi-target agents in the emerging field of polypharmacology. This digest aims to provide an overview of recent advances in sulfonamide-based bioactive compounds, their importance in drug discovery and development emphasizing multi-target approaches for complex diseases, and their novel contribution to contemporary medicinal chemistry. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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