Effect of TRPV1 on Activity of Isoforms of Constitutive Nitric Oxide Synthase during Regulation of Bicarbonate Secretion in the Stomach
| Autor: | R. P. Khropycheva, Yu. V. Andreeva, V. A. Zolotarev |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Indazoles Nitric Oxide Synthase Type III Bicarbonate TRPV1 TRPV Cation Channels Nitric Oxide Synthase Type I Sodium Chloride Vagotomy Nitroarginine General Biochemistry Genetics and Molecular Biology Amiloride Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Gastric mucosa medicine Animals Secretion Receptor biology Osmolar Concentration Stomach General Medicine Hydrogen-Ion Concentration Rats Cell biology Perfusion Phrenic Nerve Nitric oxide synthase Bicarbonates 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation chemistry Gastric Mucosa Capsaicin biology.protein Free nerve ending 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 166:310-312 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-019-04339-w |
| Popis: | Application of mild irritants (1 M NaCl; pH 2.0) on the gastric mucosa potentiates the protective secretion of bicarbonates by epithelial cells. This response is mainly mediated by capsaicin-sensitive afferent nerve endings located in the submucosa. It was shown that activation of vanilloid type 1 receptors (TRPV1) induced by exogenous acidification of GM is not sufficient to potentiate the production of HCO3, including production depending on neuronal NO synthase. However, the effect of exogenous acid on TRPV1 leads to activation of endothelial NO synthase that restrict the gastric secretion of [Formula: see text]. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink