Long-term efficacy of haloperidol in autistic children: continuous versus discontinuous drug administration
| Autor: | Phillip Adams, Richard Perry, Magda Campbell, John E. Overall, Elizabeth L. Curren, Nona Lynch, Spencer Ek |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Dyskinesia Drug-Induced Irritability Drug Administration Schedule Drug withdrawal Developmental and Educational Psychology medicine Haloperidol Humans Autistic Disorder Child Drug administration Placebo period medicine.disease Psychiatry and Mental health Dyskinesia Treatment Schedule Anesthesia Child Preschool Female medicine.symptom Psychology medicine.drug |
| Zdroj: | Journal of the American Academy of Child and Adolescent Psychiatry. 28(1) |
| ISSN: | 0890-8567 |
| Popis: | The aim of this study was to evaluate the long-term efficacy of haloperidol in autistic children and to determine whether discontinuous drug administration was as effective as continuous drug administration. Sixty children, 48 males and 12 females, ages 2.3 to 7.9 years (X 5.1) completed the study. They received haloperidol over a period of 6 months followed by a 4-week drug withdrawal/placebo period. Haloperidol remained effective, and the discontinuous treatment schedule did not diminish its efficacy. Children with prominent symptoms of irritability, angry and labile affect, and uncooperativeness were the best responders to haloperidol. |
| Databáze: | OpenAIRE |
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