Fenofibrate differently alters expression of genes encoding ATP-binding transporter proteins of the peroxisomal membrane
| Autor: | C. Causeret, Jean-Louis Mandel, Sabrina Albet, Patrick Aubourg, Bugaut Maurice, Marc Bentejac |
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| Rok vydání: | 1997 |
| Předmět: |
Biophysics
ATP-binding cassette transporter Peroxisome Biology ATP Binding Cassette Transporter Subfamily D ATP Binding Cassette Transporter Subfamily D Member 1 Microbodies Biochemistry Mice Fenofibrate Structural Biology Genetics medicine Animals RNA Messenger Adrenoleukodystrophy Molecular Biology Gene Messenger RNA Membrane Proteins Proteins Transporter Intracellular Membranes Cell Biology medicine.disease Rats Gene Expression Regulation ATP-Binding Cassette Transporters ABC transporter Function (biology) medicine.drug |
| Zdroj: | FEBS Letters. 405:394-397 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/s0014-5793(97)00122-1 |
| Popis: | The 70-kDa peroxisomal membrane protein (PMP70), adrenoleukodystrophy protein (ALDP) and adrenoleukodystrophy-related protein (ALDRP) belong to the ATP-binding transporter family, share a structure of half-transporters and are localized in the peroxisomal membrane of mammals. It was suggested that these proteins may heterodimerize to form functional transporters. The expression of the three genes was examined in various tissues of control or fenofibrate (a peroxisome proliferator)-treated rats using Northern and immuno-blotting techniques. The patterns of tissue expression were distinct for the three genes. Upon treatment, expression of the ALD gene was not altered while that of the PMP70 and ALDR genes was strongly increased in intestine and liver, respectively. The absence of coordinated expression excludes that the three transporters function as exclusive and obligatory partners. We also report for the first time that the ALDR gene is inducible in rodents and that the corresponding mRNA is different in length in rat (3.0 and 5.5 kb) and in mouse and human (4.2 kb). |
| Databáze: | OpenAIRE |
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