Association between polymorphisms of estrogen receptor 2 and benign prostatic hyperplasia
| Autor: | Young Ock Kim, Jae Hong Ann, Su Kang Kim, Joo-Ho Chung, Jun Ho Kim, Hyun Chul Park, Koo Han Yoo, Hun Kuk Park, Byung-Cheol Lee, Sang Hyup Lee |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty business.industry Prostate Diseases Haploview Haplotype Estrogen receptor Single-nucleotide polymorphism Articles General Medicine Odds ratio Hyperplasia urologic and male genital diseases Bioinformatics medicine.disease Immunology and Microbiology (miscellaneous) Internal medicine Medicine Allele business |
| Zdroj: | Experimental and Therapeutic Medicine. 10:1990-1994 |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Estrogens and estrogen receptors (ESRs) have been implicated in the stimulation of aberrant prostate growth and the development of prostate diseases. The aim of the present study was to investigate four single nucleotide polymorphisms (SNPs) of the ESR2 gene in order to examine whether ESR2 is a susceptibility gene for benign prostatic hyperplasia (BPH). In order to evaluate whether an association exists between ESR2 and BPH risk, four polymorphisms [rs4986938 (intron), rs17766755 (intron), rs12435857 (intron) and rs1256049 (Val328Val)] of the ESR2 gene were genotyped by direct sequencing. A total of 94 patients with BPH and 79 control subjects were examined. SNPStats and Haploview version 4.2 we used for the genetic analysis. Multiple logistic regression models (codominant1, codominant2, dominant, recessive and log-additive) were produced in order to obtain the odds ratio, 95% confidence interval and P-value. Three SNPs (rs4986938, rs17766755 and rs12435857) showed significant associations with BPH (rs4986938, P=0.015 in log-additive model; rs17766755, P=0.033 in codominant1 model, P=0.019 in dominant model and P=0.020 in log-additive model; rs12435857, P=0.023 in dominant model and P=0.011 in log-additive model). The minor alleles of these SNPs increased the risk of BPH, and the AAC haplotype showed significant association with BPH (χ2=6.34, P=0.0118). These data suggest that the ESR2 gene may be associated with susceptibility to BPH. |
| Databáze: | OpenAIRE |
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