Hepatobiliary and pancreatic manifestations in inflammatory bowel diseases: a referral center study

Autor: Gerasimos Baltayiannis, Vasileios Theopistos, Leonidas Christou, Epameinondas V. Tsianos, Fotios S. Fousekis, Maria Kosmidou, Konstantinos H. Katsanos, Georgios K. Glantzounis, Dimitrios K. Christodoulou
Rok vydání: 2019
Předmět:
Male
medicine.disease_cause
Gastroenterology
Inflammatory bowel disease
0302 clinical medicine
Crohn Disease
Liver Function Tests
Adrenal Cortex Hormones
Cholelithiasis
Pancreatic manifestations
medicine.diagnostic_test
General Medicine
Hepatitis B
Hepatitis C
Ulcerative colitis
030220 oncology & carcinogenesis
Acute Disease
Immunomodulators
Acute pancreatitis
Female
030211 gastroenterology & hepatology
Chemical and Drug Induced Liver Injury
Immunosuppressive Agents
Research Article
Adult
medicine.medical_specialty
Cholangitis
Sclerosing
Primary sclerosing cholangitis
03 medical and health sciences
Fatty liver
Internal medicine
medicine
Humans
lcsh:RC799-869
Retrospective Studies
Hepatobiliary manifestations
Hepatitis B virus
business.industry
Hepatotoxicity
medicine.disease
Pancreatitis
lcsh:Diseases of the digestive system. Gastroenterology
Colitis
Ulcerative
Liver function
Liver function tests
business
Zdroj: BMC Gastroenterology
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-8 (2019)
ISSN: 1471-230X
Popis: Background Hepatobiliary and pancreatic manifestations have been reported in patients with Crohn’s disease or ulcerative colitis. Our aim was to describe the prevalence of hepatobiliary and pancreatic manifestations in inflammatory bowel disease and their association with the disease itself and the medications used. Methods Data were retrospectively extracted from the clinical records of patients followed up at our tertiary IBD referral Center. Results Our study included 602 IBD patients, with liver function tests at regular intervals. The mean follow-up was 5.8 years (Std. Dev.: 6.72). Abdominal imaging examinations were present in 220 patients and revealed findings from the liver, biliary tract and pancreas in 55% of examined patients (120/220). The most frequent findings or manifestations from the liver, biliary tract and pancreas were fatty liver (20%, 44/220), cholelithiasis (14.5%, 32/220) and acute pancreatitis (0.6%, 4/602), respectively. There were 7 patients with primary sclerosing cholangitis. Regarding hepatitis viruses, one-third of the patients had been tested for hepatitis B and C. 5% (12/225) of them had positive hepatitis B surface antigen and 13.4% had past infection with hepatitis B virus (positive anti-HBcore). In addition, most of the patients were not immune against hepatitis B (negative anti-HBs), while 3% of patients were anti-HCV positive and only one patient had active hepatitis C. Furthermore, 24 patients had drug-related side effects from the liver and pancreas. The side effects included 21 cases of hepatotoxicity and 3 cases of acute pancreatitis. Moreover, there were two cases of HBV reactivation and one case of chronic hepatitis C, which were successfully treated. Conclusion In our study, approximately one out of four patients had some kind by a hepatobiliary or pancreatic manifestation. Therefore, it is essential to monitor liver function at regular intervals and differential diagnosis should range from benign diseases and various drug related side effects to severe disorders, such as primary sclerosing cholangitis.
Databáze: OpenAIRE
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