Relationship between air pollution levels in Madrid and the natural history of idiopathic pulmonary fibrosis: severity and mortality
| Autor: | Carlos J Carpio Segura, Prudencio Díaz-Agero Álvarez, Isabel Rodriguez, Ester Zamarrón De Lucas, Concepción Prados Sánchez, Pablo Mariscal Aguilar, María Fernández-Velilla Peña, Gema Bonilla Hernán, Elena Villamañán Bueno, María Isabel Torres Sánchez, Rodolfo Álvarez-Sala Walther, Rita María Regojo Zapata, Luis Gómez Carrera |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Medicine (General) medicine.medical_specialty air pollution Air pollution Idiopathic pulmonary fibrosis medicine.disease_cause urban center Biochemistry carbon monoxide 03 medical and health sciences R5-920 0302 clinical medicine Air pollutants Disease severity Humans Medicine 030212 general & internal medicine Aged Retrospective Studies Air Pollutants business.industry Biochemistry (medical) Retrospective cohort study Cell Biology General Medicine Middle Aged medicine.disease mortality Natural history 030228 respiratory system Spain Emergency medicine Particulate Matter disease severity business Retrospective Clinical Research Report |
| Zdroj: | Journal of International Medical Research, Vol 49 (2021) The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/03000605211029058 |
| Popis: | Objective We aimed to assess the relationship between major air pollutants and the natural history and mortality of idiopathic pulmonary fibrosis (IPF). Methods We conducted a retrospective cohort study from 2013 to 2019 among 52 patients with IPF from the pneumology department of a tertiary hospital. According to their geocoded residential address, each patient was assigned a mean concentration of carbon monoxide (CO), nitrogen dioxide, particulate matter 2.5 and 10, ozone, and sulfur dioxide, as measured at a single surveillance station in central Madrid, Spain. We analyzed forced vital capacity (FVC), CO diffusing capacity, 6-minute walking test, degree of dyspnea, radiologic pattern, and signs of pulmonary hypertension in all patients. Results Patients’ mean age was 66 ± 10 years, and 79% were men. The mean predicted FVC was 78.9 ± 0.5%. Forty-two patients met the criteria for severe disease, and 18 patients died. Mortality was significantly associated with increased CO exposure (for each 0.1 mg/m2 increase: odds ratio 2.45, 95% confidence interval 1.39–4.56). We observed no association between any of the other investigated contaminants and IPF mortality or severity. Conclusions Air pollution, specifically that caused by carbon monoxide, can increase mortality in patients with IPF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|