Polarization-sensitive optical coherence tomography in end-stage lung diseases
| Autor: | Eduard A. van de Graaf, Fabio Feroldi, Johannes F. de Boer, Erik Thunnissen, Johanna M. Kwakkel-van Erp, Joy Willemse, Reinier R. Wener, Margherita Vaselli |
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| Přispěvatelé: | LaserLaB - Biophotonics and Microscopy, Biophotonics and Medical Imaging, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Systems & Network Neuroscience, VU University medical center |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pathology Lumen (anatomy) Cystic fibrosis Article SDG 3 - Good Health and Well-being In vivo Internal medicine medicine Biology Computer. Automation COPD Lung business.industry Physics respiratory system medicine.disease Atomic and Molecular Physics and Optics respiratory tract diseases Chemistry Pulmonology medicine.anatomical_structure business Ex vivo Hypersensitivity pneumonitis Biotechnology |
| Zdroj: | Willemse, J, Wener, R R, Feroldi, F, Vaselli, M, Kwakkel-van Erp, J M, van de Graaf, E A, Thunnissen, E & de Boer, J F 2021, ' Polarization-sensitive optical coherence tomography in end-stage lung diseases : an ex vivo pilot study ', Biomedical Optics Express, vol. 12, no. 11, pp. 6796-6813 . https://doi.org/10.1364/BOE.435870 Biomedical Optics Express, 12(11), 6796-6813. The Optical Society Willemse, J, Wener, R R, Feroldi, F, Vaselli, M, Kwakkel-Van Erp, J M, van de Graaf, E A, Thunnissen, E & de Boer, J F 2021, ' Polarization-sensitive optical coherence tomography in end-stage lung diseases : an ex vivo pilot study ', Biomedical Optics Express, vol. 12, no. 11, pp. 6796-6813 . https://doi.org/10.1364/BOE.435870 Biomed Opt Express Biomedical optics express |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/BOE.435870 |
| Popis: | A non-invasive diagnostic tool to assess remodeling of the lung airways caused by disease is currently missing in the clinic. Measuring key features such as airway smooth muscle (ASM) thickness would increase the ability to improve diagnosis and enable treatment evaluation. In this research, polarization-sensitive optical coherence tomography (PS-OCT) has been used to image a total of 24 airways from two healthy lungs and four end-stage diseased lungs ex vivo, including fibrotic sarcoidosis, chronic obstructive pulmonary disease (COPD), fibrotic hypersensitivity pneumonitis, and cystic fibrosis. In the diseased lungs, except COPD, the amount of measured airway smooth muscle was increased. In COPD, airway smooth muscle could not be distinguished from surrounding collagen. COPD lungs showed increased alveolar size. 3D pullbacks in the same lumen provided reproducible assessment of airway smooth muscle (ASM). Image features such as thickened ASM and size/presence of alveoli were recognized in histology. The results of this study are preliminary and must be confirmed with further ex vivo and in vivo studies. PS-OCT is applicable for in vivo assessment of peribronchial and peribronchiolar lung structures and may become a valuable tool for diagnosis in pulmonology. |
| Databáze: | OpenAIRE |
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