A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases

Autor: Osamu Komiyama, Hisao Yoshida, Noriko Onishi, Masataka Ishimura, Shouichi Ohga, Chie Kobayashi, Eiji Ota, Hiroko Kozan, Yachiyo Kurihara, Ryo Niiya, Toshio Heike, Ryo Kadoya, Toshiro Hara, Tomohiro Katsuta, Toshihiko Mori, Yoshiyuki Yamada, Tomoko Waragai, Takashi Ishige, Takahiro Yasumi, Takahiro Uehara, Hiroyuki Toda, Akira Hayakawa, Satoru Kumaki, Yutaka Suzuki, Masumi Seto, Kanako Kudo, Masako Kikuchi, Hisanori Nishio, Takayuki Hoshina, Takuya Hara, Yumi Mizuno, Hidetoshi Takada, Noriko Ohbuchi, Tomoyuki Imagawa, Hiroyuki Shimizu, Maiko Igarashi, Etsuro Nanishi, Yuko Ishizaki, Masayoshi Nagao, Yutaka Saikawa, Shuhei Yajima, Yoshio Kusumoto, Shunji Hasegawa, Tomoko Sato, Hideo Tsuda, Takuro Ohno, Shohei Ogata, Yoji Sasahara, Kyouko Suzuki, Toshihiko Shirakawa
Rok vydání: 2016
Předmět:
Male
Rotavirus
0301 basic medicine
Microbiology (medical)
Herpesvirus 3
Human
Pediatrics
medicine.medical_specialty
Cellular immunity
Adolescent
viruses
Population
Respiratory Syncytial Virus Infections
Nationwide survey
medicine.disease_cause
Rotavirus Infections
Virus
03 medical and health sciences
Chickenpox
0302 clinical medicine
Surveys and Questionnaires
Influenza
Human
medicine
Humans
Prospective Studies
030212 general & internal medicine
Child
education
Respiratory Tract Infections
Response rate (survey)
education.field_of_study
business.industry
Significant difference
Immunologic Deficiency Syndromes
Infant
Newborn
Infant
Orthomyxoviridae
medicine.disease
Hospitalization
030104 developmental biology
Infectious Diseases
Child
Preschool
Respiratory Syncytial Virus
Human
Primary immunodeficiency
Female
business
Zdroj: Journal of Infection. 73:358-368
ISSN: 0163-4453
DOI: 10.1016/j.jinf.2016.07.018
Popis: Summary Objectives Patients with primary immunodeficiency diseases (PID) are highly susceptible to various microorganisms. However, no population-based studies have been performed among common viral pathogens, such as respiratory syncytial virus (RSV), rotavirus (RV), varicella-zoster virus (VZV) and influenza virus (IV). The objective of this study was to reveal the clinical burden of these four infections among PID patients in Japan. Methods We conducted a nationwide survey by sending questionnaires to 898 hospitals with pediatric departments throughout Japan. Results Nine hundred ten PID patients from 621 hospitals were registered (response rate: 69.2%). Fifty-four of the patients were hospitalized due to these viral infections. The durations of hospitalization due to RSV and RV infections differed significantly in the PID patients with and without cellular immunodeficiency (12.0 vs 6.5 days, p = 0.041 ; and 14.0 vs 6.0 days, p = 0.031 , respectively). There was no significant difference in the duration of hospitalization in PID patients with and without cellular immunodeficiency who were hospitalized with IV infections (7.3 vs 6.1 days, p = 0.53). Conclusions Special attention should be paid to PID patients with compromised cellular immunity who present with RSV and RV infection due to their high risk for severe disease.
Databáze: OpenAIRE
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