The 8-hydroxyguanine content of isolated mitochondria increases with lipid peroxidation
| Autor: | David S. Bergtold, Andrew M. Hruszkewycz |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Isolated mitochondria Mitochondrial DNA Guanine DNA damage Rats Inbred Strains General Medicine Biology Mitochondrion DNA Mitochondrial Molecular biology Rats Lipid peroxidation Membrane Lipids chemistry.chemical_compound Biochemistry chemistry Nucleic acid Animals Lipid Peroxidation DNA Damage |
| Zdroj: | Mutation Research Letters. 244:123-128 |
| ISSN: | 0165-7992 |
| DOI: | 10.1016/0165-7992(90)90060-w |
| Popis: | When lipid peroxidation was induced in isolated mitochondria there was a marked increase in the 8-hydroxyguanine content of the nucleic acids extracted from these mitochondria. The elevation of 8-hydroxyguanine levels was associated with an extensive alteration of normal electrophoretic mobility of mitochondrial DNA. However, suppression of lipid peroxidation with α-tocopherol proportionally attenuated 8-hydroxyguanine production and limited the electrophoretic mobility change of mitochondrial DNA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|