Optic nerve atrophy after vitrectomy with indocyanine green-assisted internal limiting membrane peeling in diffuse diabetic macular edema
| Autor: | Hiroshi Hirose, Fumitaka Ando, Osamu Yasui, Norio Ohba |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Indocyanine Green Male medicine.medical_specialty Visual acuity genetic structures medicine.medical_treatment Diabetic macular edema Vision Disorders Visual Acuity Vitrectomy Ilm peeling Basement Membrane Macular Edema Cellular and Molecular Neuroscience chemistry.chemical_compound Nerve Fibers Optics Ophthalmology Humans Medicine Coloring Agents Aged Retrospective Studies Aged 80 and over Diabetic Retinopathy business.industry Internal limiting membrane Optic nerve atrophy Retinal Middle Aged eye diseases Sensory Systems body regions Optic Atrophy Diabetes Mellitus Type 2 chemistry Visual Field Tests Female sense organs Visual Fields medicine.symptom business Indocyanine green Tomography Optical Coherence |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 242:995-999 |
| ISSN: | 1435-702X 0721-832X |
| DOI: | 10.1007/s00417-004-0864-4 |
| Popis: | To report anatomic and visual outcomes of vitrectomy and indocyanine green (ICG)-assisted peeling of the retinal internal limiting membrane (ILM) in the treatment of diffuse diabetic macular edema.In a retrospective interventional case series, 15 eyes of 11 patients with refractory diffuse diabetic macular edema underwent pars plana vitrectomy with removal of the ILM, which was stained by intravitreal injection of ICG (0.1-0.2 ml of 0.5% ICG), performed by a single surgeon. The patients were followed up for 14-28 months (mean 20.5 months). The main outcome measures were assessment of macular edema by optical coherence tomography and determination of visual acuity and visual field.Intravitreal ICG visualized the ILM to facilitate complete removal of the structure. Qualitative assessment of optical coherence tomography images at the end of follow-up revealed that retinal thickness in the macula appeared nearly normal with or without reappearance of foveal pit in 11 of the 15 eyes (73.3%), decreased in 3 eyes (20.0%), and did not change in 1 eye (6.6%). Best-corrected visual acuity at the end of follow-up improved by 2 lines or more in 4 eyes (26.7%), virtually unchanged in 6 eyes (40.0%), and deteriorated by 2 lines or more in 5 eyes (26.7%). The mean logMAR visual acuity was 0.680 (approximately 12/60) preoperatively and 0.812 (approximately 9/60) postoperatively, the difference being not statistically significant (paired t-test, P=0.445). Seven (46.7%) of the 15 eyes developed optic nerve atrophy that occurred gradually within 6 months after surgery and caused irreversible peripheral visual field defect predominantly affecting the nasal field.Intravitreal application of ICG is beneficial in uneventful ILM peeling to help resolution of diffuse diabetic macular edema, but it may potentially damage the optic nerve fibers and lead to unfavorable visual outcomes. |
| Databáze: | OpenAIRE |
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