Small-Colony Variants of Pseudomonas aeruginosa in Cystic Fibrosis
| Autor: | Susanne Häussler, Ivo Steinmetz, Manfred Rohde, Burkhard Tümmler, H. Weissbrodt |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Microbiology (medical) Adolescent Cystic Fibrosis Colony Count Microbial Context (language use) Comorbidity Microbial Sensitivity Tests medicine.disease_cause Sensitivity and Specificity Cystic fibrosis Statistics Nonparametric Germany medicine Tobramycin Humans Pseudomonas Infections Retrospective Studies Antibacterial agent biology Pseudomonas aeruginosa Respiratory disease Sputum Middle Aged biology.organism_classification medicine.disease Anti-Bacterial Agents Infectious Diseases Multivariate Analysis Immunology Colistin Female Pseudomonadaceae medicine.drug |
| Zdroj: | Clinical Infectious Diseases. 29:621-625 |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | In the context of chronic lung infection due to Pseudomonas aeruginosa in cystic fibrosis (CF), attention has been focused on the presence of the most common mucoid phenotype. In this study, the presence of small-colony variants (SCVs) of P. aeruginosa in respiratory tract specimens from patients with CF was investigated, and the clinical conditions predisposing to SCVs were analyzed. P. aeruginosa SCVs were isolated from 33 of 86 P. aeruginosa-positive CF patients over a 2-year period. Fast-growing revertants with larger surface colonies could be isolated from SCV populations. Electron microscopy revealed no significant difference in cell size or morphology. MICs of a broad range of antipseudomonas agents for SCVs were two- to eightfold higher than values for revertants. Recovery of SCVs was correlated with parameters revealing poor lung function and was significantly associated with daily inhalation of tobramycin or colistin. |
| Databáze: | OpenAIRE |
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