Viral infections and their relationship to neurological disorders
| Autor: | Bianca Cerqueira Dias Rodrigues, Ligia Carla Faccin-Galhardi, Jéssica Wouk, Elisa Vicente Ribelato, Daniele Zendrini Rechenchoski |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Multiple Sclerosis Review Disease Biology Guillain-Barre Syndrome medicine.disease_cause Bioinformatics Herpesviridae Pathogenesis 03 medical and health sciences Epilepsy Medical microbiology Alzheimer Disease Virology medicine Humans 030304 developmental biology Cause of death 0303 health sciences SARS-CoV-2 030306 microbiology Multiple sclerosis Flaviviridae COVID-19 Parkinson Disease General Medicine Orthomyxoviridae medicine.disease Viral Tropism Retroviridae Etiology Nervous System Diseases |
| Zdroj: | Archives of Virology |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | The chronic dysfunction of neuronal cells, both central and peripheral, a characteristic of neurological disorders, may be caused by irreversible damage and cell death. In 2016, more than 276 million cases of neurological disorders were reported worldwide. Moreover, neurological disorders are the second leading cause of death. Generally, the etiology of neurological diseases is not fully understood. Recent studies have related the onset of neurological disorders to viral infections, which may cause neurological symptoms or lead to immune responses that trigger these pathological signs. Currently, this relationship is mostly based on epidemiological data on infections and seroprevalence of patients who present with neurological disorders. The number of studies aiming to elucidate the mechanism of action by which viral infections may directly or indirectly contribute to the development of neurological disorders has been increasing over the years but these studies are still scarce. Comprehending the pathogenesis of these diseases and exploring novel theories may favor the development of new strategies for diagnosis and therapy in the future. Therefore, the objective of the present study was to review the main pieces of evidence for the relationship between viral infection and neurological disorders such as Alzheimer's disease, Parkinson's disease, Guillain-Barré syndrome, multiple sclerosis, and epilepsy. Viruses belonging to the families Herpesviridae, Orthomyxoviridae, Flaviviridae, and Retroviridae have been reported to be involved in one or more of these conditions. Also, neurological symptoms and the future impact of infection with SARS-CoV-2, a member of the family Coronaviridae that is responsible for the COVID-19 pandemic that started in late 2019, are reported and discussed. |
| Databáze: | OpenAIRE |
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