Synthesis, antimycobacterial evaluation and pharmacophore modeling of analogues of the natural product formononetin
| Autor: | Andile H. Ngwane, Kelly Chibale, Peggoty Mutai, Bienyameen Baker, Elumalai Pavadai, Ian Wiid |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.drug_class
Stereochemistry Clinical Biochemistry Antitubercular Agents Pharmaceutical Science Microbial Sensitivity Tests Antimycobacterial Biochemistry Mycobacterium tuberculosis Structure-Activity Relationship chemistry.chemical_compound Drug Discovery medicine Formononetin Molecular Biology Biological Products Natural product biology Chemistry Organic Chemistry biology.organism_classification Isoflavones Drug Design Molecular Medicine Pharmacophore Growth inhibition |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 25:2510-2513 |
| ISSN: | 0960-894X |
| Popis: | The synthesis and antimycobacterial activity of formononetin analogues is hereby reported. Formononetin and its analogue 11E showed 88% and 95% growth inhibition, respectively, against the H37Rv strain of Mycobacterium tuberculosis. Pharmacophore modeling studies indicated that the presence of a hydroxyl group in formononetin and its analogues, is crucial for maintaining activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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