Alabaster Skin after Carbon Dioxide Laser Resurfacing with Histologic Correlation

Autor: William J. Grabski, Martha L. McCollough, Eric M. Finley, Richard A. Laws
Rok vydání: 1998
Předmět:
Zdroj: Dermatologic Surgery. 24:633-636
ISSN: 1076-0512
DOI: 10.1111/j.1524-4725.1998.tb04220.x
Popis: background. Carbon dioxide laser resurfacing has gained popularity as a relatively safe and effective method of facial rejuvenation. Original reports describe mostly reversible side effects and a low incidence of scarring. Only very recently have reports of delayed hypopigmentetion surfaced. This effect is not visible until several months after resurfacing, and most likely represents a permanent change. objective. To provide an additional clinical description of the complication of delayed hypopigmentation along with the first published histologic correlation. methods. Clinical records along with a preprocedure and 7-month postprocedure full-thickness skin biopsy were used for this report. results. This patient experienced a striking leukoderma 6 months after a full facial carbon dioxide laser resurfacing procedure done for widespread actinic keratoses. There was a zone of dermal fibrosis extending approximately 0.4 mm on the postprocedure biopsy. Comparison of the preprocedure and postprocedure biopsies revealed no difference in the number of melanocytes by MART-1 immunohistochemical staining, but there was a significant decrease in epidermal melanin as determined by Fontana-Mason staining. conclusion. This patient experienced a profound expression of an increasingly recognized and reported complication of carbon dioxide laser resurfacing. Histologic correlation is similar to the results previously reported after phenol chemical peels, demonstrating a normal number of melanocytes but a decrease in epidermal melanin.
Databáze: OpenAIRE
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