Outcome of patients with uterine fibroids after 3-month ulipristal acetate therapy

Autor: Anne-Coline Monseau-Thiburce, Jean-Luc Brun, Rado Randriamboavonjy, José Rajaonarison, Alizée Froeliger, Andrej Vogler
Rok vydání: 2017
Předmět:
Adult
medicine.medical_specialty
Norpregnadienes
Antineoplastic Agents
Hormonal
Uterine fibroids
Slovenia
Drug Resistance
Pelvic Pain
Contraceptives
Oral
Hormonal
Cohort Studies
Hospitals
University
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Ulipristal acetate
Leiomyomatosis
medicine
Humans
University medical
030212 general & internal medicine
Menorrhagia
Retrospective Studies
Ultrasonography
030219 obstetrics & reproductive medicine
Leiomyoma
Obstetrics
business.industry
Pelvic pain
Previous pregnancy
Obstetrics and Gynecology
Retrospective cohort study
Abdominal distension
University hospital
medicine.disease
Magnetic Resonance Imaging
female genital diseases and pregnancy complications
Tumor Burden
Reproductive Medicine
chemistry
Uterine Neoplasms
Female
France
medicine.symptom
business
Zdroj: European journal of obstetrics, gynecology, and reproductive biology. 222
ISSN: 1872-7654
Popis: To determine the proportion and the characteristics of patients who did or did not respond after 3 months of ulipristal acetate (UPA) therapy.In this retrospective cohort study conducted in the University Hospital of Bordeaux (France) and University Medical Center Ljubljana (Slovenia), symptomatic non-menopausal patients with fibroids that qualified for surgery were pretreated by 3 months of oral UPA 5 mg/day. Clinical success was defined by normalization of the bleeding score, and/or regression of pelvic pain, and/or abdominal distension. Imaging success was defined by reduction in fibroid volume ≥ 25%.The clinical and imaging success rates were 54/66 (82%) and 39/66 (59%) respectively. The absence of previous pregnancy (p = 0.004) and the size of the dominant fibroid ≥ 80 mm (p = 0.004) were independent factors associated with clinical failure. Age35 years (p = 0.02) was the only independent factor associated with imaging failure.Young women developing fibroids and/or women with large fibroids may be resistant to ulipristal acetate therapy.
Databáze: OpenAIRE
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