Comparison of In Vitro Effects of Opioid Analgesics on Spontaneous Proximal and Distal Colon Contractions in Healthy Rats and Rats with Peritonitis
| Autor: | Cevdet Düger, Onur Avci, İdris Erşan, Ihsan Bagcivan, Iclal Ozdemir Kol, Ahmet Altun, Sinan Gursoy, Kenan Kaygusuz, Mehmet Caner Mimaroğlu |
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| Přispěvatelé: | [Ersan, Idris -- Avci, Onur] Sivas Numune Hosp, Clin Anaesthesiol, Sivas, Turkey -- [Gursoy, Sinan -- Duger, Cevdet -- Kol, Iclal Ozdemir -- Kaygusuz, Kenan -- Mimaroglu, Mehmet Caner] Cumhuriyet Univ, Sch Med, Dept Anaesthesiol, Sivas, Turkey -- [Altun, Ahmet -- Bagcivan, Ihsan] Cumhuriyet Univ, Sch Med, Dept Pharmacol, Sivas, Turkey |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
intestinal motility naloxone business.industry Perforation (oil well) Sham surgery Peritonitis Smooth muscle contraction (+)-Naloxone medicine.disease 030226 pharmacology & pharmacy 03 medical and health sciences Cecum 0302 clinical medicine Endocrinology medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine opioid medicine Morphine Ligation business medicine.drug |
| Zdroj: | Turkish Journal of Anesthesia and Reanimation. :191-196 |
| ISSN: | 2149-276X 2149-0937 |
| DOI: | 10.5152/tjar.2018.87519 |
| Popis: | WOS: 000440303300007 PubMed ID: 30140514 Objective: The goal of this study was to investigate and compare the effects of opioids on proximal and distal colon contractions in normal rats and rats with peritonitis, with and without the presence of naloxone in the environment. Methods: The study was approved by Cumhuriyet University Ethics committee. In this study, 16 Wistar Albino male rats were used. Rats were divided into two groups. Peritonitis was induced using a cecum ligation and perforation method, 24 h before the tissues of rats in the peritonitis group were collected, and sham surgery was performed 24 h before the tissues of rats in the control group were collected. Twenty-four hours after the surgery, rats' organs were harvested and hung in organ baths. Concentration-dependent inhibitory effects of morphine and meperidine on spontaneous intestinal movements were observed. Any differences between the groups were tested using the Kruskal-Wallis test, and any differences between the groups were tested using the Tukey test. Results: No significant difference was observed between the proximal and distal colon smooth muscle contraction responses in both groups after 80 mM Potassium Chloride (KCl) injection (p>0.005). In the peritonitis group, amplitudes and frequencies of spontaneous contractions in proximal and distal colon significantly increased (p0.05). In both groups, adding naloxone to the organ baths before adding opioids completely blocked the morphine's inhibitory effect on the amplitude and frequency (p |
| Databáze: | OpenAIRE |
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