Pre-natal exposures and breast tissue composition: findings from a British pre-birth cohort of young women and a systematic review
| Autor: | Amanda Eng, Mona Jeffreys, John H. Hipwell, Martin O. Leach, Isabel dos Santos Silva, David J. Hawkes, Rachel Denholm, Bianca De Stavola, Marta Cecilia Busana, Simon J. Doran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty In utero Birthweight Maternal Young Adult 03 medical and health sciences Magnetic resonance imaging 0302 clinical medicine Breast cancer Pregnancy Risk Factors medicine Humans 030212 general & internal medicine Young adult Mammary Glands Human Mammographic density Medicine(all) 2. Zero hunger Gynecology business.industry ALSPAC medicine.disease Magnetic Resonance Imaging Pre-natal United Kingdom Middle age 3. Good health Maternal Exposure Population Surveillance Prenatal Exposure Delayed Effects 030220 oncology & carcinogenesis Cohort Breast density Systematic review Mediation analysis Biomarker (medicine) Female business Body mass index Research Article Follow-Up Studies |
| Zdroj: | Breast Cancer Research : BCR Denholm, R, De Stavola, B, Hipwell, J H, Doran, S J, Busana, M C, Eng, A, Jeffreys, M, Leach, M O, Hawkes, D & dos Santos Silva, I 2016, ' Pre-natal exposures and breast tissue composition : Findings from a British pre-birth cohort of young women and a systematic review ', Breast Cancer Research, vol. 18, 102 . https://doi.org/10.1186/s13058-016-0751-z |
| ISSN: | 1465-5411 |
| DOI: | 10.1186/s13058-016-0751-z |
| Popis: | Background Breast density, the amount of fibroglandular tissue in the adult breast for a women’s age and body mass index, is a strong biomarker of susceptibility to breast cancer, which may, like breast cancer risk itself, be influenced by events early in life. In the present study, we investigated the association between pre-natal exposures and breast tissue composition. Methods A sample of 500 young, nulliparous women (aged approximately 21 years) from a U.K. pre-birth cohort underwent a magnetic resonance imaging examination of their breasts to estimate percent water, a measure of the relative amount of fibroglandular tissue equivalent to mammographic percent density. Information on pre-natal exposures was collected throughout the mothers’ pregnancy and shortly after delivery. Regression models were used to investigate associations between percent water and pre-natal exposures. Mediation analysis, and a systematic review and meta-analysis of the published literature, were also conducted. Results Adjusted percent water in young women was positively associated with maternal height (p for linear trend [p t] = 0.005), maternal mammographic density in middle age (p t = 0.018) and the participant’s birth size (p t |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink