Epidemiological serosurvey and molecular characterization of sexually transmitted infections among 1890 sheltered homeless people in Marseille: Cross-sectional one day-surveys (2000–2015)

Autor: Meriem Louni, Tran Duc Anh Ly, Hervé Tissot-Dupont, Thi Loi Dao, Philippe Brouqui, Sékéné Badiaga, Philippe Gautret, Van Thuan Hoang, Philippe Colson
Přispěvatelé: Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
HBsAg
Asia
030106 microbiology
Sexually Transmitted Diseases
HIV Infections
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Epidemiology
Prevalence
medicine
Humans
[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology
Syphilis
030212 general & internal medicine
ComputingMilieux_MISCELLANEOUS
Hepatitis
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
Treponema
biology
business.industry
1. No poverty
virus diseases
Hepatitis B
medicine.disease
biology.organism_classification
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
digestive system diseases
3. Good health
Europe
Cross-Sectional Studies
Infectious Diseases
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Health education
Underweight
medicine.symptom
business
Demography
Zdroj: Journal of Infection
Journal of Infection, 2021, 82 (1), pp.60-66. ⟨10.1016/j.jinf.2020.11.026⟩
Journal of Infection, WB Saunders, 2021, 82 (1), pp.60-66. ⟨10.1016/j.jinf.2020.11.026⟩
ISSN: 0163-4453
DOI: 10.1016/j.jinf.2020.11.026⟩
Popis: Objectives We observed the prevalence and distribution of potential risk factors for sexually transmitted infections (STIs) among Marseille homeless population. Methods Over the 2000-2015 period, we enrolled 1890 sheltered homeless adults and collected serum samples. Markers of hepatitis B and C viruses (HBV, HCV) and Treponema pallidum were searched using the CMIA testing. Positive HBsAg or anti-HCV samples underwent sequencing; positive anti-T. pallidum sera were subjected to the RPR test. Results The overall prevalence of HBsAg, anti-HBs, anti-HBc, anti-HCV and anti-T. pallidum (by CMIA and RPR) was 4.1%, 22.9%, 35.5%, 5.3% and (6.8%, 1.0%), respectively. We found a significantly higher prevalence of HBsAg and anti-T. pallidum among individuals born in sub-Saharan Africa (or Asia) compared to those born in Europe. Being older (>42 years), toxicomania status, cannabis use and underweight status (compared to normal status) were independent factors associated with HCV seropositivity. Using sequencing, we obtained a substantial diversity of HBV and HCV genotypes. One HCV sequence harbouring a L31M substitution in the NS5a protein may be associated with reduced drug sensitivity. Conclusions The positive relationship between toxicomania and HCV suggests the need for effective prevention programmes including health education activities and addiction treatment.
Databáze: OpenAIRE
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