Antimicrobial resistance trends among Salmonella isolates obtained from horses in the northeastern United States (2001-2013)
| Autor: | Kevin J. Cummings, Craig Altier, Sarah M. Khatibzadeh, Victor A. Aprea, Gillian A. Perkins, Lorin D. Warnick |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Imipenem Salmonella Veterinary medicine 040301 veterinary sciences 030106 microbiology Drug resistance Microbial Sensitivity Tests medicine.disease_cause Microbiology 0403 veterinary science 03 medical and health sciences Antibiotic resistance Anti-Infective Agents New England Drug Resistance Multiple Bacterial Prevalence Medicine Animals Horses Retrospective Studies Antiinfective agent Enrofloxacin Salmonella Infections Animal General Veterinary business.industry 04 agricultural and veterinary sciences General Medicine Tetracycline Antimicrobial Multiple drug resistance Amikacin business medicine.drug Fluoroquinolones |
| Zdroj: | American journal of veterinary research. 77(5) |
| ISSN: | 1943-5681 |
| Popis: | OBJECTIVE To describe the antimicrobial resistance patterns of Salmonella isolates obtained from horses in the northeastern United States and to identify trends in resistance to select antimicrobials over time. SAMPLE 462 Salmonella isolates from horses. PROCEDURES Retrospective data were collected for all Salmonella isolates obtained from equine specimens that were submitted to the Cornell University Animal Health Diagnostic Center between January 1, 2001, and December 31, 2013. Temporal trends in the prevalence of resistant Salmonella isolates were investigated for each of 13 antimicrobials by use of the Cochran-Armitage trend test. RESULTS The prevalence of resistant isolates varied among antimicrobials and ranged from 0% (imipenem) to 51.5% (chloramphenicol). During the observation period, the prevalence of resistant isolates decreased significantly for amoxicillin—clavulanic acid, ampicillin, cefazolin, cefoxitin, ceftiofur, chloramphenicol, and tetracycline and remained negligible for amikacin and enrofloxacin. Of the 337 isolates for which the susceptibility to all 13 antimicrobials was determined, 138 (40.9%) were pansusceptible and 192 (57.0%) were multidrug resistant (resistant to ≥ 3 antimicrobial classes). The most common serovar isolated was Salmonella Newport, and although the annual prevalence of that serovar decreased significantly over time, that decrease had only a minimal effect on the observed antimicrobial resistance trends. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that current antimicrobial use in horses is not promoting the emergence and dissemination of antimicrobial-resistant Salmonella strains in the region served by the laboratory. |
| Databáze: | OpenAIRE |
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