Serum levels of prostate specific antigen are elevated after colonoscopy
| Autor: | Feridun Sengör, Akin Özçaglayan, Fatih Güzelbulut, Mesut Sezikli, Oya Övünç Kurdaş, Hayrünnisa Sezikli, Ali Tüzün Ince, Züleyha Akkan Çetinkaya |
|---|---|
| Přispěvatelé: | İNCE, ALİ TÜZÜN |
| Rok vydání: | 2010 |
| Předmět: |
Oncology
Male medicine.medical_specialty Turkey Colorectal cancer medicine.medical_treatment Laxative Urology Colonoscopy Enema urologic and male genital diseases General Biochemistry Genetics and Molecular Biology Prostate cancer Prostate Internal medicine Cancer screening medicine Humans Analysis of Variance medicine.diagnostic_test business.industry General Medicine Middle Aged Prostate-Specific Antigen medicine.disease Prostate-specific antigen medicine.anatomical_structure business |
| Zdroj: | The Tohoku journal of experimental medicine. 222(3) |
| ISSN: | 1349-3329 |
| Popis: | The risks of prostate cancer and colorectal carcinoma increase with age. So, colonoscopy and measurement of serum prostate specific antigen (PSA) may be performed during a short term in a given patient. We aimed to evaluate whether colonoscopy affects serum PSA levels and to evaluate the relationship between prostate volume and elevation in serum PSA levels after colonoscopy. This study included 44 consecutive male patients, who underwent colonoscopy. The mean age of the patients was 56.05±9.27 years. The mean time required for colonoscopy was 30 min. Serum PSA levels were measured 48-72 hours before colonoscopy, immediately after performing laxative enema, and at 24-48th hour, the 7th day, and the 14th day after colonoscopy in each patient. The serum PSA level was elevated after enema and at 24-48th hour and 7th day after colonoscopy from the baseline (p0.05), and declined to the baseline by 14th day. When the cut off value of 20 cm3 for normal prostate volume was taken into account, the serum PSA levels were significantly higher at the 24-48th hour and the 7th day in patients with larger prostate volume (20 cm3) than those with normal prostate volume (p=0.013 and p=0.009). These results suggest that PSA is easily released by manipulations from the larger prostate. In conclusion, serum PSA levels were elevated during 7 days after colonoscopy. Before performing invasive procedures, patients with high serum PSA levels should be asked whether colonoscopy was performed prior to the measurement. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|