Low Risk of Progression of Barrett's Esophagus to Neoplasia in Women
| Autor: | Patrick E. Young, James Allen, Madhav Desai, Sreekar Vennalaganti, Fouad J. Moawad, David A. Lieberman, Manon C.W. Spaander, Srinivas Gaddam, Neil Gupta, Gary W. Falk, Prateek Sharma, Kevin F. Kennedy, Ajay Bansal, Marco J. Bruno, Sharad C. Mathur, Prashanthi N. Thota, Prashanth Vennalaganti, John J. Vargo, Carlijn A. Roumans, Brooks D. Cash, Richard E. Sampliner |
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| Přispěvatelé: | Public Health, Gastroenterology & Hepatology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Esophageal Neoplasms Lower risk Risk Assessment Cohort Studies Barrett Esophagus 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Internal medicine Humans Medicine Retrospective Studies business.industry Hazard ratio Gastroenterology Retrospective cohort study medicine.disease United States Europe Dysplasia 030220 oncology & carcinogenesis Barrett's esophagus Cohort Disease Progression Female 030211 gastroenterology & hepatology business Precancerous Conditions Body mass index Cohort study |
| Zdroj: | Journal of Clinical Gastroenterology, 55(4), 321-326. Lippincott Williams & Wilkins |
| ISSN: | 1539-2031 0192-0790 |
| Popis: | Background and Aims: Men are at a higher risk for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC), but little is known about BE progression to dysplasia and EAC in women. We performed a retrospective, multicenter cohort study to assess risk of BE progression to dysplasia and EAC in women compared with men. We also investigated comorbidities, medication use, and endoscopic features that contribute to sex differences in risk of BE progression. Methods: We collected data from large cohort of patients with BE seen at 6 centers in the United States and Europe, followed for a median 5.7 years. We obtained demographic information (age, sex, ethnicity), clinical history (tobacco use, body mass index, comorbidities), endoscopy results (procedure date, BE segment length), and histopathology findings. Neoplasia was graded as low-grade dysplasia, high-grade dysplasia (HGD), or EAC. Rates of disease progression between women and men were compared using χ2analysis and the Student t test. Multivariable logistic regression was used to assess the association between sex and disease progression after adjusting for possible confounding variables. Results: Of the total 4263 patients in the cohort, 2145 met the inclusion criteria, including 324 (15%) women. There was a total of 34 (1.6%) incident EACs, with an overall annual incidence of 0.3% (95% confidence interval: 0.2%-0.4%). We found significant differences between women and men in annual incidence rates of EAC (0.05% for women vs. 0.3% in men; P=0.04) and in the combined endpoint of HGD or EAC (0.1% for women vs. 1.1% for men; P |
| Databáze: | OpenAIRE |
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