PHA induces IL-2 receptors on B-CLL cells and is a potential biological response modifier for the LIL-2-diphtheria toxin, DAB486IL-2
| Autor: | Florecita Padua, Jean C. Nichols, John R. Murphy, Kyran Bulger, Ronald P. McCaffrey, Robert Duff, German Pihan |
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| Rok vydání: | 1994 |
| Předmět: |
musculoskeletal diseases
Interleukin 2 Cancer Research Recombinant Fusion Proteins Interleukin 5 receptor alpha subunit Biology Gamma-aminobutyric acid receptor subunit alpha-1 Interleukin 10 receptor alpha subunit medicine Tumor Cells Cultured Cytotoxic T cell Humans Immunologic Factors Diphtheria Toxin Phytohemagglutinins Receptor Interleukin 12 receptor beta 1 subunit Diphtheria toxin Immunotoxins hemic and immune systems Receptors Interleukin-2 Hematology Virology Molecular biology Leukemia Lymphocytic Chronic B-Cell biological factors Peptide Fragments Oncology Interleukin-2 medicine.drug |
| Zdroj: | Leukemia research. 18(2) |
| ISSN: | 0145-2126 |
| Popis: | DAB 486 IL-2 is an IL-2-diphtheria toxin conjugate which was developed to be specifically cytotoxic to cells bearing high affinity IL-2 receptors. The high affinity IL-2 receptor is a heterodimer comprising p55 and p75 subunits. While the p75 subunit appears to be ubiquitously expressed among the common North American leukemias and lymphomas, the p55 subunit is more restricted in its expression. To broaden the therapeutic relevance of the DAB 486 lL-2 we have sought physiologically feasible inducers of the p55 IL-2 receptor subunit. This report describes that PHA, in vitro , induces the p55 IL-2 receptor subunit on initially p55-negative B-CLL cells and converts toxin-insensitive leukemia cells to a toxin-sensitive state. |
| Databáze: | OpenAIRE |
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