Aging-associated inflammation in healthy Japanese individuals and patients with Werner syndrome
| Autor: | Masanobu Sugimoto, Yasuhiro Furuichi, Masaaki Matsuura, Kazunori Sugimoto, Yasuhiro Watanabe, Yuichi Ishikawa, Tetsuhito Ogino, Sachiko Iwaki-Egawa, Makoto Goto, Seigaku Hayashi |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Adolescent Inflammation Normal aging Biochemistry Young Adult Endocrinology Elderly population Internal medicine Genetics Humans Medicine cardiovascular diseases Child Molecular Biology Aged Werner syndrome business.industry Infant nutritional and metabolic diseases Normal population Cell Biology Middle Aged medicine.disease Highly sensitive C-Reactive Protein Child Preschool Female Werner Syndrome medicine.symptom business Biomarkers |
| Zdroj: | Experimental Gerontology. 47:936-939 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2012.08.010 |
| Popis: | Minor inflammation-driven aging (inflammaging) has been proposed to explain human aging mechanism. To study the inflammatory condition associated with normal human aging, highly sensitive CRP (hsCRP) was examined in the sera collected from 217 healthy Japanese individuals aged between 1 and 100years and 41 mutation-proven Japanese Werner syndrome (WS) patients. The serum hsCRP was assayed by ELISA. The serum hsCRP level increased significantly (p |
| Databáze: | OpenAIRE |
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