Attenuation of post-myocardial infarction depression in rats byn-3 fatty acids or probiotics starting after the onset of reperfusion
| Autor: | Thierno Madjou Bah, Jessica Arseneault-Bréard, Thomas A. Tompkins, Fabio Flores Monaco, Kim Gilbert, Roger Godbout, Guy G. Rousseau, Alexanne Beaudoin |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Bifidobacterium longum Myocardial Infarction Medicine (miscellaneous) Hippocampus Apoptosis Myocardial Reperfusion Injury Biology Proinflammatory cytokine Rats Sprague-Dawley Random Allocation Limbic system Internal medicine Fatty Acids Omega-3 Limbic System medicine Animals Myocardial infarction CA1 Region Hippocampal Neurons Nutrition and Dietetics TUNEL assay Behavior Animal Depression Probiotics Dentate gyrus food and beverages Amygdala medicine.disease biology.organism_classification Rats Lactobacillus medicine.anatomical_structure Endocrinology Dentate Gyrus Cytokines |
| Zdroj: | British Journal of Nutrition. 109:50-56 |
| ISSN: | 1475-2662 0007-1145 |
| DOI: | 10.1017/s0007114512003807 |
| Popis: | Proinflammatory cytokines play a central role in depression-like behaviour and apoptosis in the limbic system after myocardial infarction (MI). A PUFAn-3 diet or the combination ofLactobacillus helveticusR0052 andBifidobacterium longumR0175 probiotics, when given before the ischaemic period, reduce circulating proinflammatory cytokines as well as apoptosis in the limbic system. The present study was designed to determine if the same nutritional interventions maintain their beneficial effects when started after the onset of the reperfusion period and attenuate depression-like behaviour observed after MI. MI was induced by the occlusion of the left anterior descending coronary artery for 40 min in rats. After the onset of reperfusion, animals were fed with a high- or low-PUFAn-3 diet, combined or not with one billion live bacteria ofL. helveticusandB. longum. At 3 d post-MI, caspase-3 enzymatic activities and terminal 2′-deoxyuridine, 5′-triphosphate (dUTP) nick-end labelling (TUNEL)-positive cells were decreased in the CA1, dentate gyrus (DG) and amygdala with the high-PUFAn-3 diet, as compared to the three other diets. Probiotics attenuated caspase-3 activity and TUNEL-positive cells in the DG and the medial amygdala. At 2 weeks post-MI, depression-like behaviour was observed in the low-PUFAn-3 diet without probiotics-group, and this behaviour was attenuated with the high-PUFAn-3 diet or/and probiotics. These results indicate that a high-PUFAn-3 diet or the administration of probiotics, starting after the onset of reperfusion, are beneficial to attenuate apoptosis in the limbic system and post-MI depression in the rat. |
| Databáze: | OpenAIRE |
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