THE INFLUENCE OF β-TETRAHYDRONAPHTHYLAMINE AND A DERIVATIVE ON THE CENTRAL EFFECTS OF 5-HYDROXYTRYPTAMINE, RESERPINE AND IPRONIAZID
| Autor: | R. H. Thorp, Jocelyn N. Pennefather |
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| Rok vydání: | 1958 |
| Předmět: |
Serotonin
medicine.medical_specialty Reserpine medicine.drug_class Pharmaceutical Science Naphthalenes Pharmacology Niacin Hypnotic Iproniazid Serotonin Agents Smooth muscle Internal medicine medicine Chemistry Nicotinic Acids Antagonist Long-term potentiation Endocrinology Barbiturates Rat uterus Antagonism medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 10:249-252 |
| ISSN: | 2042-7158 0022-3573 |
| Popis: | N-Methyl-N-propyl-β-tetrahydromphthylamine, a specific antagonist of 5-hydroxytryptamine on the isolated rat uterus preparation, fails to inhibit 5-hydroxytryptamine potentiation of the hypnotic action of hexobarbitone in mice. The potentiating actions of reserpine and iproniazid are likewise unaffected. The action of β-tetrahydronaphthylamine as an antagonist of the potentiating action of 5-hydroxytryptamine on hexobarbitone sleeping time in mice has been confirmed, and it has also been shown to be an effective antagonist of the sleep prolonging effects of reserpine. β-Tetrahydronaphthylamine also shows a partial antagonism to iproniazid potentiation of hexobarbitone hypnosis. These results provide an example of the lack of parallelism between the central and smooth muscle actions of 5-hydroxytryptamine antagonists. |
| Databáze: | OpenAIRE |
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