Role of the Neurokinin-1 Receptors in Ejaculation in Anesthetized Rats
| Autor: | Magali Peeters, Pierre Clément, Laurent Alexandre, Miguel Laurin, François Giuliano, Jacques Bernabé |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Agonist medicine.medical_specialty Tetrahydronaphthalenes Ejaculation medicine.drug_class Urology Endocrinology Diabetes and Metabolism Bulbospongiosus muscle Substance P Isoindoles chemistry.chemical_compound Endocrinology Seminal vesicle Dopamine receptor D3 Internal medicine medicine Animals Anesthesia Rats Wistar Receptor Electromyography business.industry Penile Erection Receptors Dopamine D4 Muscle Smooth Rats Psychiatry and Mental health medicine.anatomical_structure nervous system Reproductive Medicine chemistry Dopamine Agonists NK1 receptor antagonist business |
| Zdroj: | The Journal of Sexual Medicine. 6:126-134 |
| ISSN: | 1743-6095 |
| Popis: | Introduction Several lines of evidence indicate a role for substance P in the control of ejaculation, although its mode of action needs to be clarified. Aim The effects and sites of action of a selective antagonist for the substance P-preferred receptor (neurokinin-1 receptor subtype; NK1) were investigated in a pharmacological model of ejaculation. Methods Ejaculation was induced in anesthetized rats by intracerebroventricular (icv) delivery of the dopamine D3 receptor preferring agonist 7-hydroxy-2-(di-N-propylamino)tetralin (7-OH-DPAT). The effects of the selective NK1 antagonist RP67580 on 7-OH-DPAT-induced ejaculation were measured following intraperitoneal (ip), icv, or intrathecal (it) (third lumbar spinal segment; L3) administration. Main Outcome Measures Intraseminal vesicle pressure (SVP) and electromyogram of the bulbospongiosus muscle (BS) were recorded as physiological markers of emission and expulsion phases of ejaculation, respectively. Results Upon ip, icv, or it administration, RP67580 significantly reduced the occurrence of ejaculation elicited by 7-OH-DPAT. A mild decrease in the occurrence of SVP and BS responses was observed in rats treated ip with RP67580, whereas only SVP responses were moderately affected following icv or it administration. Conclusion These results show the multilevel regulation of 7-OH-DPAT-induced ejaculation by NK1 receptors. Clement P, Peeters M, Bernabe J, Laurin M, Alexandre L, and Giuliano F. Role of the neurokinin-1 receptors in ejaculation in anesthetized rats. J Sex Med 2009;6:126–134. |
| Databáze: | OpenAIRE |
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