Brain serotonin in high-fat diet-induced weight gain, anxiety and spatial memory in rats
| Autor: | Khalid Mahmood, Darakhshan Jabeen Haleem |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Serotonin Elevated plus maze medicine.medical_specialty Normal diet Medicine (miscellaneous) Morris water navigation task Anxiety Diet High-Fat Weight Gain Open field 03 medical and health sciences 0302 clinical medicine Internal medicine Animals Medicine Hippocampus (mythology) Obesity Rats Wistar Spatial Memory 030109 nutrition & dietetics Nutrition and Dietetics business.industry General Neuroscience Leptin digestive oral and skin physiology Brain General Medicine Endocrinology medicine.symptom business Weight gain hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | Nutritional Neuroscience. 24:226-235 |
| ISSN: | 1476-8305 1028-415X |
| DOI: | 10.1080/1028415x.2019.1619983 |
| Popis: | Objectives:Effects of high-fat diet (HFD) consumption on body weight gain and its consequences on anxiety, learning and memory, and serotonin metabolism (5-hydroxytryptamine; 5-HT) in the hypothalamus and hippocampus are determined in rats.Methods:Male Wister rats treated with HFD or normal diet (ND) for 12 weeks to monitor food intakes, body weight changes, activity in an open field, anxiety in an elevated plus maze and learning/memory in Morris water maze. Animals decapitated to collect serum for determining leptin by an ELISA kit. The hippocampus and hypothalamus dissected out for determining 5-HT, its metabolite 5-hydroxyindoleacetic acid (5-HIAA) and its precursor tryptophan by HPLC-EC.Results:Despite a significant decrease in the cumulative weekly food intake, gain in body weight was greater in HFD than ND treated rats. Total caloric intakes were not different in the two groups. The consumption of HFD resulted in an enhancement of exploratory activity and reduction in anxiety. It improved le... |
| Databáze: | OpenAIRE |
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