Childhood cancer survivors face markedly worse overall survival after diagnosis with breast cancer, melanoma, or colorectal cancer
| Autor: | Shayna L. Showalter, Raj P Desai, William J. Kane, Craig L. Slingluff, Daniel E. Levin, Traci L. Hedrick, Mark A. Fleming, Kevin T. Lynch |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Adolescent Colorectal cancer Breast Neoplasms Malignancy Article 03 medical and health sciences 0302 clinical medicine Breast cancer Cancer Survivors Internal medicine Epidemiology medicine Humans Stage (cooking) Child Melanoma Aged Retrospective Studies business.industry fungi Hazard ratio Cancer General Medicine Prognosis medicine.disease Survival Rate Case-Control Studies 030220 oncology & carcinogenesis Cohort Female 030211 gastroenterology & hepatology Surgery Colorectal Neoplasms business Follow-Up Studies SEER Program |
| Zdroj: | J Surg Oncol |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/jso.26478 |
| Popis: | BACKGROUND Childhood cancer survivors (CCS) are at elevated risk of secondary malignancies (SM). Enhanced screening for SM is recommended, but compliance is poor. We hypothesized that CCS with adult-onset SM (colorectal cancer [CRC], melanoma, or breast cancer [BC]) would present with more advanced disease and have decreased overall survival (OS). METHODS The Surveillance, Epidemiology, and End Results Program was queried for patients diagnosed with cancer at age less than or equal to 18 also diagnosed with adult-onset CRC, melanoma, or BC. A cohort without a history of prior malignancy was likewise identified. Tumor features and clinical outcomes were compared. RESULTS CCS with a SM (n = 224) were compared with patients without a childhood cancer history (n = 1,392,670). CCS were diagnosed younger (BC = 37.6 vs. 61.3, p |
| Databáze: | OpenAIRE |
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