The Possible Future Roles for iPSC-Derived Therapy for Autoimmune Diseases
| Autor: | Michael J. Edel, Kevin O'Connor, Michaela Lucas, Meilyn Hew |
|---|---|
| Přispěvatelé: | Universitat de Barcelona |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Cellular therapy
lcsh:Medicine Autoimmunity Disease Review Stem cells medicine.disease_cause Bioinformatics multiple sclerosis Cell therapy pluripotent stem cells inducible medicine Induced pluripotent stem cell Autoimmune disease therapy Systemic lupus erythematosus diabetes business.industry Autoimmunitat Multiple sclerosis Teràpia cel·lular autoimmunity lcsh:R General Medicine lupus medicine.disease Stem cell business Cèl·lules mare |
| Zdroj: | Journal of Clinical Medicine, Vol 4, Iss 6, Pp 1193-1206 (2015) Dipòsit Digital de la UB Universidad de Barcelona Journal of Clinical Medicine Recercat. Dipósit de la Recerca de Catalunya instname |
| ISSN: | 2077-0383 |
| Popis: | The ability to generate inducible pluripotent stem cells (iPSCs) and the potential for their use in treatment of human disease is of immense interest. Autoimmune diseases, with their limited treatment choices are a potential target for the clinical application of stem cell and iPSC technology. IPSCs provide three potential ways of treating autoimmune disease; (i) providing pure replacement of lost cells (immuno-reconstitution); (ii) through immune-modulation of the disease process in vivo; and (iii) for the purposes of disease modeling in vitro. In this review, we will use examples of systemic, system-specific and organ-specific autoimmunity to explore the potential applications of iPSCs for treatment of autoimmune diseases and review the evidence of iPSC technology in auto-immunity to date. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|