Patients with celiac disease are at high risk of developing metabolic syndrome and fatty liver
| Autor: | Wajiha Mehtab, Vipin Gupta, Vineet Ahuja, Mahendra Singh Rajput, Govind K. Makharia, Alka Singh, Namrata Singh, Ashish Agarwal, Ashish Chauhan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
lcsh:Medicine Disease Gastroenterology 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Fatty liver Hyperlipidemia medicine 030212 general & internal medicine Obesity lcsh:RC799-869 Body mass index business.industry lcsh:R nutritional and metabolic diseases Anthropometry medicine.disease digestive system diseases Miscellaneous 030211 gastroenterology & hepatology lcsh:Diseases of the digestive system. Gastroenterology Original Article Metabolic syndrome business |
| Zdroj: | Intestinal Research Intestinal Research, Vol 19, Iss 1, Pp 106-114 (2021) |
| ISSN: | 2288-1956 1598-9100 |
| Popis: | Background/Aims: Gluten-free diet has an excess of fats and simple sugars and puts patients with celiac disease at risk of metabolic complications including metabolic syndrome and fatty liver. We assessed prevalence of metabolic syndrome and fatty liver in two cohorts of celiac disease.Methods: Study was done in 2 groups. In group 1, 54 treatment naïve patients with celiac disease were recruited. Of them, 44 returned after 1-year of gluten-free diet and were reassessed. In group 2, 130 celiac disease patients on gluten-free diet for ≥1 year were recruited. All patients were assessed for anthropometric and metabolic parameters and fatty liver. Metabolic syndrome was defined as per consensus definition for Asian Indians. Fatty liver was defined as controlled attenuation parameter value >263 decibels by FibroScan.Results: In group 1, of 44 treatment naïve patients with celiac disease, metabolic syndrome was present in 5 patients (11.4%) at baseline and 9 (18.2%) after 1 year of gluten-free diet. Patients having fatty liver increased from 6 patients (14.3%) at baseline to 13 (29.5%) after 1year of gluten-free diet (P=0.002). In group 2, of 130 patients with celiac disease on gluten-free diet for a median duration of 4 years, 30 out of 114 (26.3%) and 30 out of 130 patients (23%) had metabolic syndrome and fatty liver, respectively.Conclusions: Patients with celiac disease are at high risk of developing metabolic syndrome and fatty liver, which increases further with gluten-free diet. These patients should be assessed for nutritional and metabolic features and counseled about balanced diet and physical activity regularly. |
| Databáze: | OpenAIRE |
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