Safety of a new extensively hydrolysed formula in children with cow's milk protein allergy: a double blind crossover study
| Autor: | Suzanne W J Terheggen-Lagro, Anne Schaafsma, Erik A. K. Wauters, Ilse Khouw |
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| Jazyk: | angličtina |
| Předmět: |
Male
Adolescent Protein Hydrolysates Milk allergy medicine.disease_cause Immunoglobulin E Allergen Double-Blind Method Casein medicine Ingestion Animals Humans Food science Pediatrics Perinatology and Child Health Child Cross-Over Studies Edman degradation biology Molecular Structure business.industry lcsh:RJ1-570 Caseins Infant food and beverages lcsh:Pediatrics medicine.disease Milk Proteins Crossover study Infant Formula Molecular Weight Infant formula Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein Cattle Female Milk Hypersensitivity business Research Article |
| Zdroj: | BMC Pediatrics BMC Pediatrics, Vol 2, Iss 1, p 10 (2002) |
| ISSN: | 1471-2431 |
| DOI: | 10.1186/1471-2431-2-10 |
| Popis: | Background Formulae for infants with cow's milk protein allergy (CMA) should be based on extensively hydrolysed protein. 'Extensively' however is not strictly defined. Differences in molecular weight and peptide chain length may affect its clinical outcome. We studied the safety of a new extensively hydrolysed casein based formula (Frisolac Allergycare®: FAC) for children with IgE mediated CMA. Methods Thirty children, aged 1.5 – 14.8 years old (median 4.9 years) with persistent CMA were enrolled in this double-blind reference product (Nutramigen®: NUT) controlled crossover study. All had positive skin prick tests (SPT) and IgE mediated allergy, showing immediate reactions after ingestion of small amounts of milk. Twenty-five children also had positive radio allergen sorbent tests (RAST) to cow's milk. Formulae provided consisted of 80% elementary formula in combination with 20% reference or test product. Crossover periods lasted for two weeks. From both products molecular weight (MALDI-TOF method and HPLC) and peptide chain length distribution (adapted Edman degradation) were determined. Results Maximum molecular weights of NUT and FAC are 2.1 and 2.56 kDa, respectively. The contribution of free amino acids and small peptides Conclusions The new extensively hydrolysed casein-based formula (FAC) can safely be used in children with IgE mediated cow's milk allergy. |
| Databáze: | OpenAIRE |
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