New antibiotic, isohematinic acid. I. Taxonomy of producing organism, fermentation and isolation

Autor:	Ryuzo Enokita, Tatsuo Haneishi, Michiko Takeuchi, Seigo Iwado, Yasuhiro Itoh, Akio Torikata
Rok vydání:	1983
Předmět:	Pharmacology Chromatography Strain (chemistry) Chemistry medicine.drug_class Elution Antibiotics Extraction (chemistry) Ethyl acetate Succinimides Anti-Bacterial Agents chemistry.chemical_compound Adsorption Actinomycetales Fermentation Drug Discovery medicine Methanol
Zdroj:	The Journal of Antibiotics. 36:493-496
ISSN:	1881-1469 0021-8820
DOI:	10.7164/antibiotics.36.493
Popis:	New antibiotic, isohematinic acid, was found in the culture broth of an actinomycete strain SANK 61681, which was identified as a strain of Actinoplanes philippinensis. Fermentation of isohematinic acid was performed by conventional submerged culture in a 600-liter fermentor. Isolation of isohematinic acid was performed by adsorption of the antibiotic from the culture filtrate on a column of Diaion HP-20 followed by elution with aqueous acetone and extraction with ethyl acetate. Isohematinic acid was finally crystallized from hot methanol.
Databáze:	OpenAIRE
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