Evaluation of Later Morphologic Alterations in Renal Artery Wall and Renal Nerves in Response to Catheter-Based Renal Denervation in Sheep: Comparison of the Single-Point and Multiple-Point Ablation Catheters
| Autor: | D Richter, Zuzana Husková, Zbyněk Tonar, J Peregrin, Miloš Táborský, A Herman, T Kubíková, Libor Kopkan |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Catheters Physiology medicine.medical_treatment Urology 030204 cardiovascular system & hematology Kidney Random Allocation 03 medical and health sciences Renal Artery 0302 clinical medicine medicine.artery medicine Animals 030212 general & internal medicine Sympathectomy Renal artery Denervation Plexus Sheep business.industry General Medicine Ablation Catheter medicine.anatomical_structure Catheter Ablation Immunohistochemistry Female Histopathology business |
| Zdroj: | Physiological Research. :891-901 |
| ISSN: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.933903 |
| Popis: | This study evaluated the subacute morphologic alterations in renal artery wall and renal nerves in response to catheter-based renal denervation (RDN) in sheep and also compared the efficiency of single-point and multiple-point ablation catheters. Effect of each ablation catheter approved for the clinical use (Symplicity FlexTM, Medtronic, Inc., or EnligHTNTM, St. Jude Medical, INC.) was compared to intact contralateral renal artery in 12 sheep by histopathology and immunohistochemistry evaluation after a 10-day period post-RDN procedure. The safety was verified by extensive evaluation of kidney morphology. Vascular wall lesions and nerve injuries were more pronounced in those animals treated with multi-point EnligHTN catheter when compared with animals treated with single-point Symplicity Flex catheter. However, neither RDN procedure led to complete renal nerve ablation. Both systems, tested in the present study, provided only incomplete renal nerve ablation in sheep. Moreover, no appreciable progression of the nerve disintegration in subacute phase post-RDN procedure was observed. This study further supports the notion that the effectiveness remains fully dependent on anatomical inter-individual variability of the sympathetic nerve plexus accompanying the renal artery. Therefore, new systems providing deeper penetrance to targeted perivascular structure would be more efficient. |
| Databáze: | OpenAIRE |
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