Sex hormone receptors are expressed in identified respiratory motoneurons in male and female rats
| Autor: | Cathy F. Thomas, Mary Behan |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Hypoglossal Nerve medicine.medical_specialty medicine.drug_class Receptors Cell Surface Biology Mice Internal medicine medicine Animals Estrogen Receptor beta Humans Gonadal Steroid Hormones Receptor Estrogen receptor beta Testosterone Motor Neurons Sex Characteristics musculoskeletal neural and ocular physiology General Neuroscience fungi Estrogen Receptor alpha Sex hormone receptor musculoskeletal system Immunohistochemistry Respiratory Muscles Rats Perfusion Phrenic Nerve Androgen receptor Endocrinology nervous system Receptors Androgen Estrogen Female Receptors Progesterone Estrogen receptor alpha Hormone |
| Zdroj: | Neuroscience. 130:725-734 |
| ISSN: | 0306-4522 |
| Popis: | Sex hormones including estrogen, progesterone and testosterone can influence breathing. However, it is not clear whether such hormones exert their effects directly on respiratory motoneurons. We used immunocytochemistry to demonstrate that estrogen receptor alpha, estrogen receptor beta and androgen receptor are localized in respiratory motor neurons. Motoneurons in the hypoglossal (XII) and the phrenic nuclei were retrogradely labeled from the tongue and the diaphragm respectively. Double-label fluorescence immunocytochemistry was used to show that sex hormone receptors are present in respiratory motoneurons of both male and female rats. These data suggest that in male and female rats, sex hormones can modulate the output of respiratory motoneurons directly. |
| Databáze: | OpenAIRE |
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