Predictors of postherpetic neuralgia in patients with herpes zoster: a pooled analysis of prospective cohort studies from North and Latin America and Asia
| Autor: | Lin Yang, Tsen-Fang Tsai, Jittima Dhitavat, Camilo J. Acosta, Hee Jin Cheong, Emmanouil Rampakakis, John S. Sampalis, M Cashat-Cruz, Kosuke Kawai, Kelly D Johnson, Homero Monsanto, Alejandro Ortiz Covarrubias |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Microbiology (medical) Canada Pediatrics medicine.medical_specialty Asia Multivariate analysis Activities of daily living Argentina Taiwan Neuralgia Postherpetic urologic and male genital diseases Herpes Zoster lcsh:Infectious and parasitic diseases Quality of life Activities of Daily Living Republic of Korea medicine Humans lcsh:RC109-216 Prospective Studies Prospective cohort study Mexico Aged Pain Measurement Predictors Postherpetic neuralgia business.industry Incidence Incidence (epidemiology) General Medicine Exanthema Middle Aged Thailand medicine.disease Rash Latin America Infectious Diseases North America Multivariate Analysis Quality of Life Physical therapy Female medicine.symptom Complication business Brazil |
| Zdroj: | International Journal of Infectious Diseases, Vol 34, Iss C, Pp 126-131 (2015) |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2015.03.022 |
| Popis: | Summary Objectives The most common complication of herpes zoster (HZ) is postherpetic neuralgia (PHN), a persistent pain that can substantially affect quality of life (QoL). This analysis aimed to evaluate predictors of PHN in HZ patients. Methods A pooled analysis of prospective cohort studies of HZ patients aged ≥50 years from North America (Canada), Latin America (Brazil, Mexico, and Argentina), and Asia (Taiwan, South Korea, and Thailand) was performed. Patients within 14 days of rash onset were included. The incidence of PHN was defined as a worst pain score of ≥3, persisting/appearing at >90 days after rash onset. Socio-demographics, HZ disease characteristics, treatment, pain-related interference with activities of daily living, and health-related QoL were assessed. Results Of 702 patients with HZ, 148 (21.1%) developed PHN. Similar risks of PHN were observed across geographic regions. On multivariate analysis, older age, greater severity of pain at rash onset, employment status, walking problems at enrollment, and pain interference affecting social relationships were significantly associated with the development of PHN. Conclusions In addition to older age and severe acute pain, this study suggests that impaired physical and social functioning from acute zoster pain may play a role in the development of PHN in this prospective cohort study of HZ patients from North and Latin America and Asia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|