The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery
| Autor: | Jorid B. Sørli, M.F. Razuc, V. Bucalá, P.M. Natalini, María Verónica Ramírez-Rigo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Sodium
Pharmaceutical Science chemistry.chemical_element Nanoaggregates 02 engineering and technology INGENIERÍAS Y TECNOLOGÍAS 030226 pharmacology & pharmacy Sodium taurocholate Albendazole 03 medical and health sciences 0302 clinical medicine Pulmonary surfactant medicine Sodium glycocholate Porosity Chromatography Lung Spray drying High-pressure homogenization 021001 nanoscience & nanotechnology Dry-powder inhaler Ingeniería Química purl.org/becyt/ford/2.4 [https] Dry powder inhaler medicine.anatomical_structure chemistry purl.org/becyt/ford/2 [https] Particle size 0210 nano-technology medicine.drug |
| Zdroj: | Natalini, P M, Razuc, M F, Sørli, J B, Bucalá, V & Ramírez-Rigo, M V 2019, ' The influence of surfactant on the properties of albendazole-bile salts particles designed for lung delivery ', Journal of Drug Delivery Science and Technology, vol. 53, 101162 . https://doi.org/10.1016/j.jddst.2019.101162 CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| Popis: | Albendazole is a first line drug for the treatment of several parasitic diseases in humans. Some parasites target the lungs, however lung delivery of albendazole has so far not been reported. We have developed albendazole-based powders suitable for pulmonary delivery, and studied the impact of surfactant on the formulation properties. High-pressure homogenization followed by spray drying was used to produce inhalable particles of albendazole containing the bile salts sodium taurocholate and sodium glycocholate. The process resulted in porous microparticles, that exhibited good spray drying yield (>50%), low moisture contents ( 71%) or conditions that simulate decreased respiratory capacity (respiratory fraction > 49%). The powders did not disturb lung surfactant function. The comparison between both formulations has revealed that the properties of the surfactants affect mainly the particle size of the suspensions and the porosity of the powders. The higher porosity of the albendazole-sodium taurocholate powder led to an enhanced aerodynamic performance of the formulation compared to albendazole-sodium glycocholate. The developed albendazole powders may pave a way for local lung treatment of parasitic diseases. Fil: Natalini, Paola Marisel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. University of Southern Denmark; Dinamarca Fil: Razuc, Mariela Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina Fil: Sørli, Jorid Birkelund. The National Research Centre for the Working Environment; Dinamarca Fil: Bucala, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina Fil: Ramírez Rigo, María Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina |
| Databáze: | OpenAIRE |
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