Evaluation of candidate genes as a cause of chondrodysplasia in Labrador retrievers
| Autor: | Peter A. J. Leegwater, Herman A.W. Hazewinkel, Jedee Temwitchitr, Bouvien A.W. Brocks, Jelke Jan Smit, Peter G.J. Nikkels |
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| Rok vydání: | 2008 |
| Předmět: |
Genetic Markers
Male Candidate gene medicine.medical_specialty Genes Recessive Disease SLC26A2 Osteochondrodysplasias Dogs Recessive inheritance Internal medicine medicine Animals Genetic Predisposition to Disease Dog Diseases Gene Glycoproteins Genetics Polymorphism Genetic General Veterinary biology musculoskeletal system Endocrinology Observed Incidence Short limbs Case-Control Studies Sulfate transporter biology.protein Animal Science and Zoology Female Collagen |
| Zdroj: | Veterinary journal (London, England : 1997). 187(2) |
| ISSN: | 1532-2971 |
| Popis: | Chondrodysplasia (CD) is a disabling, hereditary disease in Labradors with short limbs, warranting genetic screening in families at risk. Segregation analysis of eight litters with 13 affected dogs showed that autosomal recessive inheritance was consistent with the observed incidence of CD in the litters. Possible involvement of eight candidate collagen genes (COL9A1, COL9A2, COL9A3, COMP, MATN3, COL2A1, COL11A1 and COL11A2) and of a sulfate transporter glycoprotein (SLC26A2) gene in eight affected dogs and in 14 related control Labradors was investigated. Assuming recessive inheritance, the candidate genes could not be implicated in CD. |
| Databáze: | OpenAIRE |
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