Effects of seizures on learning, memory, and behavior in the genetically epilespy-prone rat
| Autor: | Teresa A. Marchi, Gregory L. Holmes, Martha A. Hogan, Pamela S. Gabriel, James L. Thompson, Daniel S. Feldman, Frank G. Carl |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Water maze Audiology Electroencephalography Open field Epilepsy Memory Seizures medicine Animals Learning Memory disorder Learning memory Behavior Animal medicine.diagnostic_test Cognitive disorder Rats Inbred Strains medicine.disease Rats Acoustic Stimulation Neurology Home cage Neurology (clinical) Psychology Neuroscience |
| Zdroj: | Annals of Neurology. 27:24-32 |
| ISSN: | 1531-8249 0364-5134 |
| DOI: | 10.1002/ana.410270106 |
| Popis: | To determine whether frequent seizures can cause deficits in learning and behavior, immature genetically epilepsy-prone rats (GEPRs) were subjected to 66 audiogenic stimulations (Group 1). GEPR littermates were handled and placed in the sound chamber but were not stimulated (Group 2). Group 3 comprised genetically epilepsy-resistant rats (GERRs) who received audiogenic stimulations but had no seizures. After 3 weeks of stimulations the rats were tested for learning, memory, and behavior using the T-maze, water maze, open field activity test, home cage intruder test, and handling test. When compared with the control GEPRs and GERRs, Group 1 rats reached criteria less frequently in the T-maze, required longer times to find the platform in the water maze, and were less active in the open field activity test, less aggressive in the home cage intruder test, and more irritable and aggressive in the handling test. This study demonstrates that frequent, brief seizures in immature animals result in significant detrimental changes in learning, memory, activity level, and behavior. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text