Mice homozygous for a null mutation of activin βB are viable and fertile
| Autor: | Margaret L. Harbison, Maureen Gendron-Maguire, Thomas Gridley, Heinrich Schrewe |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Embryology Genotype Ratón Molecular Sequence Data Mutant Biology Polymerase Chain Reaction Cell Line Embryonic and Fetal Development Mice Adjuvants Immunologic Animals Coding region Allele Gene Alleles Genetics Mice Inbred BALB C Base Sequence Homozygote Embryogenesis Embryo Embryo Mammalian Molecular biology Null allele Activins Blotting Southern Fertility Mutation Female Peptides Oligopeptides Developmental Biology |
| Zdroj: | Mechanisms of Development. 47:43-51 |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/0925-4773(94)90094-9 |
| Popis: | We have made a null mutation in the mouse activin beta B gene by deleting the portion of the gene encoding the proteolytic cleavage site and the majority of the coding region for the mature processed protein. Mice homozygous for this mutation complete embryogenesis and are completely viable. Approximately 40% of the homozygous mutant animals are born with open eyes. Aside from the incompletely penetrant eye defects, histopathological analysis has not revealed any other abnormalities in homozygous mutant animals. Breeding tests have shown that both male and female homozygous mutant animals are fertile. |
| Databáze: | OpenAIRE |
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