68Ga-PSMA-HBED-CC PET/CT imaging in Black versus White South African patients with prostate carcinoma presenting with a low volume, androgen-dependent biochemical recurrence
| Autor: | Ismaheel O. Lawal, Thomas Ebenhan, Christophe Van de Wiele, Tebatso Boshomane, Mike Sathekge, Mariza Vorster, Jan Rijn Zeevaart, Thabo Lengana, Alex Maes, Alfred O. Ankrah, Neo P. Mokgoro |
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| Rok vydání: | 2018 |
| Předmět: |
Glutamate Carboxypeptidase II
Male Biochemical recurrence medicine.medical_specialty Urology Tumor burden Black People Pet ct imaging Gallium Radioisotopes urologic and male genital diseases White People 030218 nuclear medicine & medical imaging South Africa 03 medical and health sciences 0302 clinical medicine Recurrence Positron Emission Tomography Computed Tomography medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study Edetic Acid Aged business.industry Prostatic Neoplasms General Medicine Prostate carcinoma Tumor Burden Low volume Androgen dependent 030220 oncology & carcinogenesis Antigens Surface Androgens Recurrent Prostate Carcinoma business |
| Zdroj: | Nuclear Medicine Communications. 39:179-185 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/mnm.0000000000000791 |
| Popis: | Objective To compare the diagnostic accuracy of Ga-prostate-specific membrane antigen (PSMA)-HBED-CC PET/computed tomography (CT) imaging for the detection of androgen-dependent recurrent prostate carcinoma (ADPC) in Black South Africans (BSAs) versus White South Africans (WSAs) with increasing serum prostate-specific antigen (PSA) values below or equal to 10 ng/ml. Patients and methods A total of 61 patients with ADPC were prospectively included in the study (mean age: 66.7 years): 38 WSAs and 23 BSAs. Ga-PSMA-HBED-CC PET/CT imaging results obtained were related to serum PSA levels and to ethnicity. Results A total of 41 (67%) patients had a positive Ga-PSMA-HBED-CC scan result. Ga-PSMA-HBED-CC PET/CT positivity was significantly higher in patients with PSA values more than 2 ng/ml [32/38 (84%) patients] when compared with patients with PSA values less than 0.5 ng/ml [6/11 (55%) patients] or PSA values of 0.5-2 ng/ml [3/12 (25%) patients] (P=0.0001). Mean PSA values proved not significantly different in patients presenting with extrapelvic involvement when compared with those with intrapelvic involvement or between patients who presented with bone involvement versus those who did not on Ga-PSMA-HBED-CC PET/CT) (P≥0.147). Age, Gleason-scores, median PSA values, the frequency of a positive scan result, the frequency of bone involvement, and extrapelvic involvement proved similar in WSAs and BSAs (P≥0.417). Conclusion Ga-PSMA-HBED-CC PET/CT imaging identified a recurrence in 67% of the patients under study. Higher PSA levels were associated with Ga-PSMA-HBED-CC PET/CT positivity and the detection rate. Imaging results obtained proved similar in BSAs and WSAs, suggesting that the tumor burden and growth rate of ADPC are similar in both races. |
| Databáze: | OpenAIRE |
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